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Changes in whey proteome with lactation stage and parity in dairy cows using a label-free proteomics approach

文献类型： 外文期刊

作者： Yang, Yongxin 1 ; Zheng, Nan 1 ; Zhao, Xiaowei 1 ; Yang, Jinhui 1 ; Zhang, Yangdong 1 ; Han, Rongwei 1 ; Zhao, Shenggu 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr & Rural Affairs, Key Lab Qual & Safety Control Milk & Dairy Prod, Beijing 100193, Peoples R China

2.Anhui Acad Agr Sci, Anhui Key Lab Livestock & Poultry Prod Safety Eng, Inst Anim Sci & Vet Med, Hefei 230031, Peoples R China

3.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao, Peoples R China

关键词： Lactation; Parity; Principal component analysis; Proteomics; Whey protein

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2020 年 128 卷

页码：

收录情况： SCI

摘要： Milk yield and several components of milk that are affected by physiological factors have been widely investigated. However, the effects of lactation stage and parity on bovine milk whey proteins have not been well elucidated. To aid in unraveling the proteome profile and exploring the protein biosynthesis of mammary glands, a label-free proteomic approach was used to characterize whey proteomes depending on the lactation stage and parity of dairy cows. The results of this study show that the abundances of several proteins, such as early lactation protein, syntenin, and heparanase, were associated with specific stages of the lactation cycle; this was evidenced by a principal component analysis. In addition, several proteins, such as hemoglobin subunits beta and alpha, beta-lactoglobulin, CD320, and apolipoprotein E, corresponded to the parity of the dairy cows and were herein considered as useful biomarkers to distinguish different parities. Most of the differentially expressed proteins from specific lactation stages and parity milk groups were annotated in the response to stimulus and protein metabolic processes. The findings reveal that developmental changes in whey proteomes correspond to lactation stages and parities, which in turn provides new insight into the underlying implications of the production of specific proteins to meet the health benefits of offspring and host, and allow us to explore the mechanisms of protein biosynthesis in mammary glands associated with physiological changes in dairy cows.

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