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Long-term bound gossypol administration damages the liver and reproductive functions of male mice

文献类型： 外文期刊

作者： Zhang, Chen 1 ; Shu, Gangqin 1 ; Zhou, Kerui 1 ; You, Yaojie 1 ; Liu, Ruian 1 ; Chen, Jiashun 3 ; Jiang, Qian 3 ; Yin, Yulong 3 ; Chen, Lijuan 1 ;

作者机构： 1.Anhui Agr Univ, Coll Anim Sci & Technol, Biol Feedstuff Lab, Hefei 230036, Anhui, Peoples R China

2.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei 230011, Peoples R China

3.Hunan Agr Univ, Coll Anim Sci & Technol, Anim Nutr Genome & Germplasm Innovat Res Ctr, Changsha 410128, Hunan, Peoples R China

4.Guiding Cty Anim Husb & Aquat Affairs Ctr, Chenzhou 423500, Hunan, Peoples R China

关键词： Bound gossypol; Liver injury; Sperm; Reproductive function

期刊名称：ANNALS OF AGRICULTURAL SCIENCES （ 影响因子：3.2； 五年影响因子：6.1 ）

ISSN： 0570-1783

年卷期： 2024 年 69 卷 2 期

页码：

收录情况： SCI

摘要： Gossypol is an anti-nutritional factor in cottonseed products, and its toxicity is reduced mainly by transforming free gossypol (FG) to bound gossypol (BG). However, the safety of BG chronic consumption in relation to liver and reproduction has not been fully examined. This study aimed to assess the effects of chronic BG exposure on liver and male reproductive function. BG with a purity of 97.38 % was prepared from whole egg solution and acetate gossypol, and its digestive stability was investigated by in vitro and in vivo digestion experiments. In vitro, digestion experiment of BG in the simulated gastric and intestinal fluid was performed. In vivo, thirty 8-week-old male C57BL/6 mice were randomly assigned into 3 groups, and the effects of BG on the liver and reproductive function of mice were studied by administering 24.8 mg/(kg center dot BW) BG (contains 0.67 mg FG) (marked as BG group), through gavage for 90 days, and administrated with 0.67 mg/(kg center dot BW) FG as a control group (C group), administrated with vehicle as a negative control group. Results show that BG dissociated into FG in simulated gastrointestinal environments. Long-term BG administration hindered the growth performance of the male mice, during which higher FG was detected in the feces of BG-administrated mice. This BG administration also increased serum alanine aminotransferase and aspartate aminotransferase levels, as well as the balloon degeneration and binucleate cells in the liver. Sperm concentration, sperm motility, epididymis coefficient, and the lactate dehydrogenase-X activity in the testis were inhibited by BG administration. Taken together, we reported that long-term administration with BG at a low dosage of 24.8 mg/(kg center dot BW) damages the growth performance, liver, and reproductive function, which may guide the modest use of cottonseed in foods and feeds.

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