Effects of Magnolia officinalis extract on the growth performance and immune function of weaned piglets
文献类型： 外文期刊
作者： Zhang, Chen 1 ; Liu, Bifan 1 ; Cui, Zhijuan 1 ; Wu, Kunfu 1 ; Huang, Haibo 1 ; Wang, Yongliang 1 ; Ma, Xiaokang 1 ; Tan, Bi'e 1 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Key Lab Qual Regulat Livestock & Poultry Prod Huna, Changsha 410128, Peoples R China
2.Inst Anim Husb & Vet Med, Anhui Acad Agr Sci, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei 230031, Peoples R China
3.Yuelushan Lab, Changsha 410128, Peoples R China
4.Inst Yunnan Circular Agr Ind, Puer 665000, Peoples R China
关键词： Magnolia officinalis extract; Weaned piglet; Growth performance; Immunity function
期刊名称：PORCINE HEALTH MANAGEMENT （ 影响因子：3.1； 五年影响因子：3.3 ）
ISSN：
年卷期： 2025 年 11 卷 1 期
页码：
收录情况： SCI
摘要： Background Magnolia officinalis is a medicinal herb known for its pharmacological properties and as a potential natural feed additive. We aimed to assess the effects of dietary Magnolia officinalis extract (MOE) on the growth performance and immune function of piglets, and explored the potential of MOE as a natural alternative to antibiotics for piglet nutrition during weaning. Results Compared with the basal diet group (CK), the MOE diet significantly increased average daily feed intake and reduced diarrhea incidence and serum interleukin-6 (IL-6) levels. Compared with 0.1% MOE group, the 0.05% MOE group had lower diarrhea rates, eosinophils (EOS) count, EOS' percentage, and serum interleukin-4 levels. Compared with CK, 0.05% MOE supplementation in the diet could reduce the diarrhea incidence and the thymus index by elevating the levels of transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10) in the serum, jejunum, and ileum. Compared with the basal diet group, 0.05% MOE supplementation upregulated the mRNA expressions of IL-10 and TGF-beta 1 in the jejunum and ileum (P < 0.05) and those of IL-10, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma) in the thymus (P < 0.05). Moreover, 0.05% MOE increased the levels of butyric, isobutyric, isovaleric, and valeric acids in the colon. Conclusions MOE supplementation could modulate the immune status of animals, lower production costs, and contribute to more sustainable and ethical pig farming practices by promoting healthier growth and reducing disease susceptibility. Our findings offer a sustainable solution to antibiotic use in animal farming, addressing concerns about antibiotic resistance and food safety.
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