Lactobacillus fermentum ZC529 Protects Intestinal Epithelial Barrier Integrity by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway
文献类型： 外文期刊
作者： Yuan, Zian 1 ; Huang, Lang 1 ; Hu, Zhenguo 4 ; Deng, Junhao 1 ; Duan, Yehui 4 ; Jiang, Qian 1 ; Tan, Bi'e 1 ; Ma, Xiaokang 1 ; Zhang, Chen 1 ; Tang, Xiongzhuo 1 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Prov Key Lab Prod Qual Regulat Livestock & P, Changsha 410128, Peoples R China
2.Yuelushan Lab, Changsha 410128, Peoples R China
3.Kagoshima Univ, Fac Agr, Korimoto, Kagoshima 8900065, Japan
4.Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Peoples R China
5.Inst Yunnan Circular Agr Ind, Puer 665000, Peoples R China
6.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei 230031, Peoples R China
关键词：
期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）
ISSN：
年卷期： 2025 年 14 卷 6 期
页码：
收录情况： SCI
摘要： The probiotic bacteria Lactobacillus fermentum ZC529 (L.f ZC529) has been identified from the colon of the Diannan small-ear (DSE) pig, but its intestinal protective function still lacks investigation. Here, we established a dextran sodium sulfate (DSS)-induced intestinal oxidative stress model in both Drosophila and porcine small intestinal epithelial (IPEC-J2) cell lines to explore the anti-oxidative and anti-inflammatory effects of L.f ZC529. The data showed that the intestinal colonization of L.f ZC529 counteracted DSS-induced intestinal oxidative stress and excessive reactive oxygen species (ROS) generation by activation of the CncC pathway, a homology of the nuclear factor erythroid 2-related factor 2 (Nrf2) in mammalian systems. Moreover, L.f ZC529 supplementation prevented flies from DSS-induced intestinal barrier damage, inflammation, abnormal excretory function, and shortened lifespan. Finally, L.f ZC529 also attenuated DSS-induced intestinal injury in the IPEC-J2 cell line by activating the Keap1-Nrf2 signaling and inhibiting the NF-kappa B signaling pathways. Together, this study unraveled the profound intestinal protective function of L.f ZC529 and provides its potential application as a new antioxidant in improving animal intestinal health as well as in developing a new probiotic in the food industry.
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