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Deoxynivalenol interferes with intestinal motility via injuring the contractility of enteric smooth muscle cells: A novel hazard to the gastrointestinal tract by environmental toxins

文献类型： 外文期刊

作者： Ji, Xu 1 ; Qiao, Yu 1 ; Zheng, Weijiang 1 ; Jiang, Honglin 3 ; Yao, Wen 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, 1 Weigang Rd, Nanjing 210095, Peoples R China

2.Anhui Acad Agr Sci, Anhui Prov Key Lab Livestock & Poultry Product Sa, Inst Anim Sci & Vet Med, Hefei 230031, Peoples R China

3.Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

4.Nanjing Agr Univ, Key Lab Anim Physiol & Biochem, Minist Agr & Rural Affairs Peoples Republ China, Nanjing 210095, Peoples R China

关键词： Environmental toxins; Deoxynivalenol; Intestinal motility; Enteric smooth muscle cells; Contractility

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2021 年 224 卷

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is a prevalent Fusarium mycotoxin, occurs predominantly in the global environment, especially in cereals, animal feed and food commodities. The widespread contamination causes a serious risk to human and animal health. DON usually impairs weight gain, which is presumably from its capacity to reduce feed intake by interfering with intestinal motility. To clarify the role of smooth muscle cells (SMCs) contractility intestinal motility and growth inhibition caused by DON, twelve weaned piglets were firstly divided into two groups to feed control or Fusarium mycotoxin-contaminated (MC) diet. Results showed that the final body weight, average daily gain and average daily feed intake were significantly reduced in piglets fed the MC diet. Exposure to the MC diet also significantly decreased the thickness of smooth muscle layer and SMCs contractile markers expression (myosin heavy chain 11, smooth muscle actin gamma 2, transgelin, calponin 1) in jejunum and ileum of piglets. Furthermore, oral DON supplementation (3 mg/kg body weight) to mice in six consecutive days could significantly inhibit the upper intestinal transit, impede normal defecation and downregulate SMCs contractile markers expression in small intestine. Finally, we generated a porcine enteric smooth muscle cell line (PISMC), and found that DON could depress its contractility by decreasing PISMC proliferation, migration and contractile markers expression. In conclusion, these findings in vivo and in vitro suggest that DON, as a common environmental toxin, can not only reduce proliferative and motile phenotype, but also decrease contractile apparatus components (contractile markers expression) in SMCs, which in turn influences SMCs contractility and then interferes with intestinal motility and growth performance.

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