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New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets

文献类型： 外文期刊

作者： Zhang, Feng 1 ; Chen, Mengxian 1 ; Liu, Xiaodan 1 ; Ji, Xu 3 ; Li, Shenghe 1 ; Jin, Erhui 1 ;

作者机构： 1.Anhui Sci & Technol Univ, Coll Anim Sci, Chuzhou, Peoples R China

2.Anhui Prov Key Lab Anim Nutr Regulat & Hlth, Chuzhou, Peoples R China

3.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei, Peoples R China

关键词： Weaned piglet; Endoplasmic reticulum stress; Unfolded protein response; Anterior gradient 2; Intestinal barrier function

期刊名称：ANIMAL NUTRITION （ 影响因子：6.3； 五年影响因子：6.9 ）

ISSN： 2405-6383

年卷期： 2023 年 15 卷

页码：

收录情况： SCI

摘要： Sustained dysfunction of the intestinal barrier caused by early weaning is a major factor that induces postweaning diarrhea in weaned piglets. In both healthy and diseased states, the intestinal barrier is regulated by goblet cells. Alterations in the characteristics of goblet cells are linked to intestinal barrier dysfunction and inflammatory conditions during pathogenic infections. In this review, we summarize the current understanding of the mechanisms of the unfolded protein response (UPR) and anterior gradient 2 (AGR2) in maintaining intestinal barrier function and how modifications to these systems affect mucus barrier characteristics and goblet cell dysregulation. We highlight a novel mechanism underlying the UPR-AGR2 pathway, which affects goblet cell differentiation and maturation and the synthesis and secretion of mucin by regulating epidermal growth factor receptor and mucin 2. This study provides a theoretical basis and new insights into the regulation of intestinal health in weaned piglets.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

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