Chitinase involved in immune regulation by mediated the toll pathway of crustacea Procambarus clarkii
文献类型： 外文期刊
作者： Liu, Min 1 ; Chen, Chen 4 ; Wu, Qi-Cheng 2 ; Chen, Jia-Le 3 ; Dai, Li-Shang 3 ; Chu, Sheng Hui 1 ; Liu, Qiu-Ning 2 ;
作者机构： 1.Shihezi Univ, Sch Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832003, Peoples R China
2.Yancheng Teachers Univ, Sch Wetlands, Yancheng 224007, Peoples R China
3.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China
4.Anhui Agr Univ, Coll Life Sci, 130 Changjiang West Rd, Hefei 230036, Anhui, Peoples R China
5.Anhui Acad Agr Sci, Fishery Inst, Anhui Prov Key Lab Aquaculture & Stock Enhancemen, Hefei 230031, Peoples R China
关键词： Chitinase; Innate immunity; PcChitinase 2 gene; Procambarus clarkii; Toll pathway
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）
ISSN： 1050-4648
年卷期： 2021 年 110 卷
页码：
收录情况： SCI
摘要： Chitinase can degrade chitin and play an essential role in animal immunity and plant defense. The immune functions of Chitinase in Procambarus clarkii (P. clarkii) remain to elucidate. Here, we identified PcChitinase 2 gene sequence from P. clarkii and studied its spatial and temporal expression profiles. The PcChitinase 2 transcribed unequally in different tissues; however, its expression was highest in those of stomach, gut, and hepatopancreas. The challenge with lipolysaccharide or peptidoglycan significantly up-regulated the expression of PcChitinase 2 in hepatopancreas. The knockdown of the PcChitinase 2 gene by double-stranded RNA suppressed most of the Toll-pathway-related immune genes (phospholipase, lectin, sptazle Cactus, serine proteikinase, antilipopolysaccharide factor, and Toll) production were significantly increased. Our results suggest PcChitinase 2 may be involved in the innate immune responses of P. clarkii by modulating the toll pathway.
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