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Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits

文献类型： 外文期刊

作者： Jing, Jing 1 ; Jiang, Xichun 3 ; Zhu, Cuiyun 1 ; Zheng, Qi 1 ; Ji, Qianyun 1 ; Yin, Huiqun 4 ; Huang, Jingtong 1 ; Zhu, Y 1 ;

作者机构： 1.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Anhui, Peoples R China

2.Anhui Agr Univ, Anhui Prov Key Lab Local Livestock & Poultry Gene, Hefei 230036, Anhui, Peoples R China

3.Anhui Acad Agr Sci, Inst Anim Sci & Vet Med, Hefei 230031, Anhui, Peoples R China

4.901st Hosp, Reprod Med Ctr, Hefei 230031, Anhui, Peoples R China

关键词： miRNA; Skeletal muscle; sRNA-seq; Rabbit; Development

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2021 年 22 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundmiRNA is one of the crucial roles in the complex and dynamic network that regulates the development of skeletal muscle. The landscape of skeletal muscle miRNAs from fetus to adult in New Zealand rabbits has not been revealed yet.ResultsIn this study, nine RNA-seq libraries of fetus, child and adult rabbits' leg muscles were constructed. A total of 278 differentially expressed miRNAs (DEmiRNAs) were identified. In the fetus vs. child group, the main functional enrichments were involved in membrane and transport. Pathway enriched terms of up-regulated DEmiRNAs were connected with the differentiation and hypertrophy of skeletal muscle, and down-regulated ones were related to muscle structure and metabolic capacity. In the child vs. adult group, functions were associated to positioning and transportation, and pathways were relevant to ECM, muscle structure and hypertrophy. Finally, ocu-miR-185-3p and ocu-miR-370-3p, which had the most target genes, were identified as hub-miRNAs in these two groups.ConclusionsIn short, we summarized the highly expressed and uniquely expressed DEmiRNAs of fetus, child and adult rabbits' leg muscles. Besides, the potential functional changes of miRNAs in two consecutive stages have been explored. Among them, the ocu-miR-185-3p and ocu-miR-370-3p with the most target genes were selected as hub-miRNAs. These data improved the understanding of the regulatory molecules of meat rabbit development, and provided a novel perspective for molecular breeding of meat rabbits.

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