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Comprehensive Analysis of LncRNA Reveals the Temporal-Specific Module of Goat Skeletal Muscle Development

文献类型： 外文期刊

作者： Ling, Yinghui 1 ; Zheng, Qi 1 ; Sui, Menghua 1 ; Zhu, Lu 1 ; Xu, Lina 2 ; Zhang, Yunhai 1 ; Liu, Ya 1 ; Fang, Fugui 1 ; Chu, 1 ;

作者机构： 1.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Anhui, Peoples R China

2.Newcastle Univ, Sch Nat & Environm Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

3.Local Anim Genet Resources Conservat & Biobreedin, Hefei 230031, Anhui, Peoples R China

4.Anhui Acad Agr Sci, Inst Plant Protect & Agroprod Safety, Hefei 230036, Anhui, Peoples R China

5.Chinese Acad Agr Sci, Key Lab Farm Anim Genet Resources & Germplasm Inn, Minist Agr, Beijing 100193, Peoples R China

关键词： lncRNA; skeletal muscle; transcriptome; goat; development

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1661-6596

年卷期： 2019 年 20 卷 16 期

页码：

收录情况： SCI

摘要： A series of complex processes regulate muscle development, and lncRNAs play essential roles in the regulation of skeletal myogenesis. Using RNA sequencing, we profiled the lncRNA expression during goat (Capra hircus) skeletal muscle development, which included seven stages across fetal 45 (F45), 65 (F65), 90 (F90), 120 (F120), 135 (F135) days, born for 24 h (B1) and 90 (B90) days. A total of 15,079 lncRNAs were identified in the seven stages, and they were less conservative with other species (human, cow, and mouse). Among them, 547 were differentially expressed, and they divided the seven stages into three functional transition periods. Following weighted gene co-expression network analysis (WGCNA), five lncRNA modules specific for developmental stages were defined as three types: Early modules', late modules', and individual-stage-specific modules'. The enrichment content showed that early modules' were related to muscle structure formation, late modules' participated in the p53 signaling pathway' and other pathways, the F90-highly related module was involved in the MAPK signaling pathway', and other pathways. Furthermore, we identified hub-lncRNA in three types of modules, and LNC_011371, LNC_ 007561, and LNC_001728 may play important roles in goat skeletal muscle. These data will facilitate further exploration of skeletal muscle lncRNA functions at different developmental stages in goats.

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