The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research
文献类型： 外文期刊
作者： Zhang, Jinfu 1 ; Khazalwa, Emmanuel M. 3 ; Abkallo, Hussein M. 3 ; Zhou, Yuan 1 ; Nie, Xiongwei 1 ; Ruan, Jinxue 1 ; Z 1 ;
作者机构： 1.Huazhong Agr Univ, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Swine Genet & Breeding, Wuhan 430070, Peoples R China
3.Int Livestock Res Inst ILRI, Biosci, Anim & Human Hlth Program, POB 30709, Nairobi 00100, Kenya
4.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med,Key Lab Pig Mol Quantita, Anhui Prov Key Lab Livestock & Poultry Prod Safet, Livestock & Poultry Epidem Dis Res Ctr Anhui Prov, Hefei 230031, Kenya
5.Huazhong Agr Univ, Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China
6.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Minist Agr, Genome Anal Lab,Lingnan Guangdong Lab Modern Agr, Shenzhen 518124, Peoples R China
关键词： CRISPR/Cas9; Swine; Genome editing; CRISPR screening; Base editing
期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：4.275； 五年影响因子：5.223 ）
ISSN： 1673-8527
年卷期： 2021 年 48 卷 5 期
页码：
收录情况： SCI
摘要： Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. In addition, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research, such as animal breeding, vaccine development, xenotransplantation, and disease modeling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
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