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cDNA cloning and polymorphic domains of the major histocompatibility complex (MHC) class I alpha in two Chinese native chicken breeds

文献类型： 外文期刊

作者： Dai, Yin 1 ; Liu, Xuelan 1 ; Ye, Hong 1 ; Chen, Fangfang 1 ; Liu, Shengjie 1 ; Yu, Weiyi 1 ;

作者机构： 1.Anhui Agr Univ, Key Lab Zoonoses Anhui Prov, Hefei, Peoples R China

2.Anhui Acad Agr Sci, Inst Anim Husb & Vet Sci, Hefei, Peoples R China

关键词： Chinese native chicken;MHC class I alpha;alpha 1 and alpha 2 domains;polymorphism

期刊名称：AFRICAN JOURNAL OF BIOTECHNOLOGY （ 影响因子：0.573； 五年影响因子：0.794 ）

ISSN： 1684-5315

年卷期： 2011 年 10 卷 65 期

页码：

收录情况： SCI

摘要： Major histocompatibility complex (MHC) is a highly polymorphic gene and plays an important role in immune system for vertebrate. To understand the polymorphism character of domestic, we cloned 32 cDNAs of MHC class I alpha genes of two local chicken breeds in different areas of China. There were 112 variable amino acid residues in all five domains (leader peptide, alpha 1, alpha 2, alpha 3 and TM/CY domains) of the putative alpha chain, and 76 of them were located in alpha 1 and alpha 2 domains. There were 23 to 25 polymorphic sites with high mutation frequency in alpha 1 and alpha 2 domains. Comparison of chicken with duck, human and mouse revealed that the two domains were highly similar among different species, and some highly polymorphic sites were located at the sites 9, 111(114), 113 (116) and 153 (156). Analysis of the phylogenetic tree indicated no relationship between the breeds and polymorphic alleles. All these results therefore indicate that MHC I class molecule of domestic chickens was more influenced by the pressure of common pathogens rather than geographic differences.

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