Effects of adding antibiotics to an inactivated oil-adjuvant avian influenza vaccine on vaccine characteristics and chick health
文献类型: 外文期刊
作者: Shen, Xuehuai 1 ; Zhang, Anyun 3 ; Zhao, Ruihong 1 ; Yin, Lei 1 ; Yin, Dongdong 1 ; Dai, Yin 1 ; Hou, Hongyan 1 ; Wang, Jieru 1 ; Hu, Xiaomiao 1 ; Pan, Xiaocheng 1 ; Zhang, Danjun 1 ; Liu, Wei 1 ; Liu, Yongjie 2 ; Zhan, Kai 1 ;
作者机构: 1.Anhui Acad Agr Sci, Inst Anim Husb & Vet Sci, Livestock & Poultry Epidem Dis Res Ctr Anhui Prov, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei 230031, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China
3.Sichuan Univ, Anim Dis Prevent & Food Safety Key Lab Sichuan Pro, Key Lab Bioresource & Ecoenvironm, Coll Life Sci,Minist Educ, Chengdu 610064, Peoples R China
关键词: avian influenza vaccines; antibiotic; immunization effect; drug concentration; chick health
期刊名称:POULTRY SCIENCE ( 影响因子:3.8; 五年影响因子:4.1 )
ISSN: 0032-5791
年卷期: 2024 年 103 卷 10 期
页码:
收录情况: SCI
摘要: During poultry immunization, antibiotics are typically added to inactivated oil-adjuvant avian influenza (AI) vaccines. Here, we evaluated the effects of adding ceftiofur, a third-generation cephalosporin, to an AI vaccine on vaccine stability and structure and on chick growth, immune efficacy, blood concentrations, biochemical and immunological indices, and gut microbiota. The results demonstrated that neither aqueous ceftiofur sodium nor ceftiofur hydrochloride oil emulsion formed a stable mixture with the vaccine. Adding ceftiofur formulations, particularly ceftiofur hydrochloride, at >4% significantly destabilized the vaccine's water-in-oil structures. Adding ceftiofur also increased vaccine malabsorption at the injection site; specifically, adding ceftiofur hydrochloride reduced H5N8 and H7N9 antibody titers after the first immunization (P P < 0.05) and H7N9 antibody titers after the second immunization (P P < 0.01). Serum drug concentrations did not differ significantly between the groups with ceftiofur sodium and hydrochloride addition. Ceftiofur addition increased postvaccination chick weight loss; compared with the vaccine alone, ceftiofur sodium-vaccine mixture increased chick weight significantly (P P < 0.05). Ceftiofur addition also increased stress indices and reduced antioxidant capacity significantly (P P < 0.05 or P < 0.01). Vaccination-related immune stress reduced gut microbiota diversity in chicks; ceftiofur addition reversed this change. AI vaccine immunization significantly reduced the relative abundance of Lactobacillus and Muribaculaceae but significantly increased that of Bacteroides and Eubacterium coprostanoligenes group. Ceftiofur addition restored the gut microbiota structure; in particular, ceftiofur hydrochloride addition significantly increased the abundance of the harmful gut microbes Escherichia-Shigella and Enterococcus, , whereas ceftiofur sodium addition significantly reduced it. The changes in gut microbiota led to alterations in metabolic pathways related to membrane transport, amino acids, and carbohydrates. In conclusion, adding ceftiofur to the AI vaccine had positive effects on chick growth and gut microbiota modulation; however, different antibiotic concentrations and formulations may disrupt vaccine structure, possibly affecting vaccine safety and immunization efficacy. Thus, the addition of antibiotics to oil-adjuvant vaccines is associated with a risk of immunization failure and should be applied to poultry with caution.
- 相关文献
作者其他论文 更多>>
-
Identification and Gene Cloning of a Brittle Culm Mutant (bc22) in Rice
作者:Cao, Xiying;Zhou, Tao;Liu, Wei;Zou, Yu;Ma, Hui;Gu, Dongfang;Ni, Jinlong;Cao, Xiying;Sun, Yue;Xu, Huan;Chen, Qingquan;Zhang, Yuhan;Gu, Dongfang;Ni, Jinlong
关键词:rice; brittle culm mutant; cell wall components; gene mapping
-
Genomic evolution and insights into agronomic trait innovations of Sesamum species
作者:Miao, Hongmei;Wei, Shuangling;Zheng, Yongzhan;Duan, Yinghui;Li, Chun;Zhao, Ruihong;Mu, Cong;Tian, Qiuzhen;Gao, Tongmei;Zhang, Haiyang;Wang, Lei;Sun, Yamin;Lin, Wenchao;Xiong, Songjin;Qu, Lingbo;Wang, Xuede;Liu, Hongyan;Le, Meiwang;Wang, Qiang
关键词:Sesamum; genome evolution; structural variation; plant architecture; Fusarium wilt disease; oil content
-
IFI16 plays a critical role in avian reovirus induced cellular immunosuppression and suppresses virus replication
作者:Zhang, Chengcheng;Zhang, Qingqing;Zhang, Xiaorong;Wu, Yantao;Zhang, Chengcheng;Zhang, Qingqing;Zhang, Xiaorong;Wu, Yantao;Li, Wei;Hu, Xiaomiao
关键词:Avian reovirus; p17; IFI16; IFN-b; protein interaction
-
High-Performance Detection of Mycobacterium bovis in Milk Using Recombinase-Aided Amplification-Clustered Regularly Interspaced Short Palindromic Repeat-Cas13a-Lateral Flow Detection
作者:Wang, Jieru;Zeng, Xiaoyu;Yin, Dongdong;Gou, Jiaojiao;Pan, Xiaocheng;Wang, Nan;Xu, Lei;Cheng, Junsheng;Zhang, Xiaoqian;Zhang, Yinghui;Zhu, Xiaojie
关键词:milk; food safety; bovine tuberculosis; CRISPR-Cas13a; rapid detection
-
Improving broiler health through cecal microbiota transplantation: a comprehensive study on growth, immunity, and microbial diversity
作者:Khalid, Anam;Huang, Zhengxuan;Khan, Ibrar Muhammad;Khalid, Fatima;Nassar, Nourhan;Jiang, Xinyu;Wang, Zaigui;Cheng, Maoji;Zhan, Kai;Wang, Zaigui
关键词:cecal microbiota transplantation; chicken; growth performance; immunity; microbial diversity; storage condition
-
Isolation, characterization, evaluation of pathogenicity, and immunomodulation through interferon production of duck adenovirus type-3 (DAdV-3)
作者:Tan, Yang;Rahim, Muhammad Ajwad;Xin, Huang;Zhou, Yuhang;Hu, Xuerui;Chen, Fangfang;Raheem, Muhammad Akmal;Raheem, Muhammad Akmal;Dai, Yin;Ataya, Farid Shokry
关键词:DAdV-3; separation; pathogenicity; interferon; cytokine
-
Dietary supplementation of Astragalus fermentation products improves the growth performance, immunological characteristics, and disease resistance of crucian carp (Carassius auratus)
作者:Shi, Lisha;Xue, Mingyang;Xing, Yangyang;Xu, Chen;Jiang, Nan;Fan, Yuding;Chen, Jianwu;Liu, Wei;Zeng, Lingbing;Zhou, Yong;Shi, Lisha;Wu, Yeying;Wu, Minglin
关键词:fermentation; growth characteristics; disease resistance; crucian carp; Astragalus