您好，欢迎访问安徽省农业科学院 机构知识库！

Sequence analysis of the haemagglutinin genes of H9N2 avian influenza viruses isolated in China during 1996 to 2011

文献类型： 外文期刊

作者： Dai, Yin 1 ; Wang, Junjun 2 ; Xu, Fazhi 3 ; Zhao, Ruihong 1 ; Hu, Xiaomiao 1 ; Zhang, Danjun 1 ;

作者机构： 1.Anhui Acad Agr Sci, Inst Anim Husb & Vet Sci, Hefei 230031, Peoples R China

2.Anim Husb & Vet Bur Xuancheng City, Xuancheng 242000, Peoples R China

3.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Peoples R China

关键词： Avian influenza virus;H9N2 subtype;hemagglutinin gene;sequence analysis

期刊名称：JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT （ 影响因子：0.435； 五年影响因子：0.484 ）

ISSN： 1459-0255

年卷期： 2012 年 10 卷 1 期

页码：

收录情况： SCI

摘要： To understand the molecular characteristics of H9N2 avian influenza viruses (AIV), we studied 21 amino acid sequences of haemagglutinin (HA) genes, which were gained from strains in different areas of China during 1996 to 2011. There were 99 variable amino acid residues, accounting for 17.7% of all amino acids. Nine polymorphic amino acid residues (score >= 4) were observed in the chicken HA, the HA 1 domain showed higher level of mutation than the HA2 domain. Moreover, the result showed that the 3 sites (218-220, 298-300, 305-307) were variable in 7 potential glycosylation positions. There were 7 receptor-binding sites, especially the site 198 with high degree of mutation frequency located in the globular head of protein model. It revealed the site 198 might be more conducive to changing AIV virus to adapt to new hosts and to evade the body's immune system. Phylogenetic tree showed that no significant regional differentiation was found in HA amino acid sequences of strains. It indicated that geographical isolation of virus could be broken by extensive trades and migration of birds.

  • 相关文献

[1]Bioinformatics analysis of amino acid sequence of acetylcholinesterase from Bemisia tabaci Genn. (Hemiptera: Aleyrodidae). Chen, Dexin,Tang, Qingfeng,Chen, Dexin,Zhou, Benguo. 2013

[2]Characterization of the genome structure of Bombyx mori densovirus (China isolate). Wang, Yong Jie,Yao, Qin,Chen, Ke Ping,Wang, Yong,Lu, Jian,Han, Xu. 2007

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：安徽省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台