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Characterization, antioxidant activity and immunomodulatory activity of polysaccharides from the swollen culms of Zizania latifolia

文献类型： 外文期刊

作者： Wang, Mingchun 1 ; Zhu, Peilei 1 ; Zhao, Shiwei 1 ; Nie, Chenzhipeng 1 ; Wang, Naifu 1 ; Du, Xianfeng 1 ; Zhou, Yibin 1 ;

作者机构： 1.Anhui Agr Univ, Dept Food Sci & Engn, Hefei 230036, Peoples R China

2.Anhui Prov Agr Prod Proc Engn Lab, Hefei 230036, Peoples R China

3.Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA

4.Anhui Acad Agr Sci, Inst Hort, Hefei 230031, Peoples R China

关键词： Polysaccharide;Zizania latifolia;Characterization;Antioxidant activity;Immunomodulatory activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： The swollen culms of Zizania latifolia have been used as a vegetable and traditional herbal medicine in China, Japan, Korea and Southeast Asia countries. Up to date, there is little information about the polysaccharides from the swollen culms of Zizania latifolia and their potential bioactivities. In the present study, water extractable polysaccharide (ZLPs-W) and alkali extractable polysaccharide (ZLPs-A) was sequentially prepared from the swollen culms of Zizania latifolia. Both of ZLPs-W and ZLPs-A was found to be non-starch polydisperse heterpolysaccharide with beta-type glycosidic linkage. ZLPs-W with triple helix conformation mainly composed of GalA, Glc and Gal. ZLPs-A without triple helix conformation mainly composed of Glc, Gal, XyI and Ara. In in vitro antioxidant assay, ZLPs-W and ZLPs-A exhibited good scavenging activities. The EC50 of DPPH radical, superoxide radical and hydroxy radical scavenging activities for ZLPs-A is 1.87, 1.13 and 0.38 mg/mL compared with that for ZLPs-W is 2.95, 3.99 and 0.5 mg/mL, respectively. Moreover, in vitro cell assay revealed that ZLPs-W without cytotoxicity has higher immunomodulatory activity than ZLPs-A in terms of stimulation of phagocytic ability and NO production in murine macrophage RAW 264.7. At the treated concentration of 400 mu g/mL and 100 mu g/mL, ZLPs-W induced a highest phagocytosis index (1.76) and NO product (29.12 mu mol/L), respectively. The results suggest that polysaccharide from the swollen culms of Zizania latifolia could be explored as potential natural antioxidant and immunomodulatory agents in medicine or functional food fields. (C) 2016 Elsevier B.V. All rights reserved.

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