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MHC class I BFIV gene polymorphisms in four Chinese native chicken breeds

文献类型： 外文期刊

作者： Dai, Yin 1 ; Liu, Xue-Lan 2 ; Tang, Qing-Feng 2 ; Hu, Xiao-Miao 1 ; Shen, Xue-Huai 1 ; Zhang, Dan-Jun 1 ;

作者机构： 1.Anhui Acad Agr Sci, Inst Anim Husb & Vet Sci, Hefei 230031, Peoples R China

2.Anhui Agr Univ, Hefei 230036, Peoples R China

关键词： Chinese native chicken;MHC class I BFIV gene;Peptide-binding region;Polymorphism

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）

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收录情况： SCI

摘要： The major histocompatibility complex (MHC) includes the most polymorphic genes in vertebrates, and balancing selection has been proposed as a main evolutionary force. Here we present one of the first data sets examining the genetic characteristics of chicken MHC I BFIV molecules in four Chinese native breeds, sourced from different regions in China. In all, 89 BFIV alleles were isolated from 102 individuals sampled, and 13 repeated alleles were observed. No significant correlation was found between genetic differentiation and geographical distance in the phylogenetic tree. BFIV genes exhibited a high level of nucleotide polymorphisms, and most of the polymorphic sites were located in the peptide-binding region (PBR) encoded in exons 2 and 3. A comparison of the three-dimensional structures of PBRs in chicken BFIV and human HLA-A molecules revealed evident structural and functional similarities. The results suggested that MHC I molecules had similar structural features in different species. (C) 2016 Elsevier Ltd. All rights reserved.

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