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Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle

文献类型： 外文期刊

作者： Wang, Zezhao 1 ; Zhu, Bo 1 ; Niu, Hong 1 ; Zhang, Wengang 1 ; Xu, Ling 1 ; Xu, Lei 1 ; Chen, Yan 1 ; Zhang, Lupei 1 ; Gao, X 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Innovat Team Cattle Genet Breeding, Beijing 100193, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Key Lab Anim Genet Breeding & Reprod,Minist Agr, Beijing 100193, Peoples R China

3.Anhui Acad Agr Sci, Inst Anim Husb & Vet Res, Hefei 230031, Anhui, Peoples R China

关键词： Chinese Wagyu cattle; Fatty acids; GWAS; Meat quality; Pleiotropic effects

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 2049-1891

年卷期： 2019 年 10 卷

页码：

收录情况： SCI

摘要： BackgroundFatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study (GWAS) on fatty acid composition using high-density single nucleotide polymorphism (SNP) arrays in Chinese Wagyu cattle.ResultsIn total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase (SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5 (PLSCR5), Cytoplasmic linker associated protein 1 (CLASP1), and Chymosin (CYM). Notably, we found the top candidate SNP within SCD can explain similar to 7.37% of phenotypic variance for C14:1 cis-9. Moreover, we detected several blocks with high LD in the 100kb region around SCD. In addition, we found three significant SNPs within a 100kb region showing pleiotropic effects related to multiple FA groups (PUFA, n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2 (BAIAP2L2), MAF bZIP transcription factor F (MAFF), and transmembrane protein 184B (TMEM184B).ConclusionsOur study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle.

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