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Huangshan Floral Mushroom Polysaccharide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating Th17/Treg Balance in a Gut Microbiota-Dependent Manner

文献类型： 外文期刊

作者： Zou, Ming-yue 1 ; Wang, Yu-jing 1 ; Liu, Yong 2 ; Xiong, Shan-qiang 2 ; Zhang, Lei 3 ; Wang, Jun-hui 1 ;

作者机构： 1.Hefei Univ Technol, Engn Res Ctr Bioproc, Minist Educ, Hefei 230009, Peoples R China

2.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China

3.Anhui Acad Agr Sci, Sericultural Res Inst, Hefei 230061, Peoples R China

关键词： floral mushroom; gut microbiota; polysaccharides; Th17; Treg balance; ulcerative colitis

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：6.575； 五年影响因子：6.883 ）

ISSN： 1613-4125

年卷期：

页码：

收录情况： SCI

摘要： ScopeUlcerative colitis (UC) is a common chronic recurrent inflammatory bowel disease. This study attempts to reveal the improvement mechanism of floral mushroom polysaccharide (FMPS) on UC from the perspective of coordinated interaction between intestinal microbes and intestinal helper T cell 17 (Th17)/regulatory T cell (Treg) balance. Methods and resultsDextran sulfate sodium (DSS)-induced colitis mice model is used for the experiment. The results suggest that FMPS up-regulated the expression of occludin, ZO-1, and MUC2, and down-regulated the secretion of TNF-alpha, IL-1 beta, and IL-6 in colitis mice. Importantly, FMPS restores intestinal Th17/Treg balance. Meanwhile, FMPS can regulate intestinal microorganisms and improve the level of short-chain fatty acids (SCFAs) in colitis mice. Intestinal microbial depletion and fecal microbiota transplantation (FMT) experiments reveal that FMPS ameliorated UC is mediated by intestinal microbiome. Flow cytometry further proves that FMPS restores intestinal Th17/Treg balance in a microbial-dependent manner. ConclusionThese results indicate that FMPS has the potential to improve UC, and its mechanism depends on the restoration of Th17/Treg balance mediated by intestinal microorganisms. Therefore, it is suggested that FMPS dietary supplement can be potentially used to intervene UC.

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