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Gill Transcriptome, Proteome, and Histology in Female Eriocheir sinensis Under Copper Stress

文献类型： 外文期刊

作者： Pan, Tingshuang 1 ; Li, Tong 1 ; Yang, Min 1 ; Yu, Chengchen 1 ; Jiang, He 1 ; Ling, Jun 1 ;

作者机构： 1.Anhui Acad Agr Sci, Fishery Inst, Hefei 230031, Peoples R China

2.Key Lab Aquaculture & Stock Enhancement Anhui Prov, Hefei 230031, Peoples R China

关键词： gene; protein; histology; Chinese mitten crab

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 10 期

页码：

收录情况： SCI

摘要： Cu is a chemical contaminant that is toxic to aquatic animals at certain concentrations. The present study describes the gill transcriptome, proteome, and histology of the Chinese mitten crab (Eriocheir sinensis) subjected to copper stress. Female 14-month-old E. sinensis (n = 60) crabs (79.6 +/- 4.8 g, body weight) were randomly divided into two groups and subjected to copper stress at concentrations of 0 mu g/L (Blank group, GBL) and 50 mu g/L (Copper group, GCP) for 96 h. In total, 278 upregulated and 189 downregulated differentially expressed genes (DEGs) were identified in the GBL and GCP groups. In addition, upregulated and downregulated differentially expressed proteins (DEPs) in the GBL and GCP groups were 260 and 308, respectively. An integrated analysis demonstrated that the three DEGs overlapped between the two omics approaches. Comparative omics analysis indicated that seven GO terms were significantly (p < 0.05) enriched by overlapping DEGs in the transcriptome and proteome. Further analysis revealed that only one overlapping DEG (stumps) was enriched in two common KEGG pathways, the PI3K-Akt and B cell receptor signaling pathways. Histological analyses showed that copper-stressed gills had collapsed lamellae with enlarged marginal vessels and shortened interlamellar spaces due to the disruption of the pillar cells and cuticles. These results demonstrate the variations in copper-stressed gills and will be helpful for better understanding the mechanisms of copper toxicity in E. sinensis.

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