Subchronic Exposure to Microcystin-LR Induces Hepatic Inflammation, Oxidative Stress, and Lipid Metabolic Disorders in Darkbarbel Catfish (Tachysurus vachelli)
文献类型： 外文期刊
作者： Zhou, Huaxing 1 ; Li, Tong 1 ; Wang, Huan 1 ; Zhang, Ye 1 ; Hu, Yuting 1 ; Liu, Amei 1 ; Duan, Guoqing 1 ;
作者机构： 1.Anhui Acad Agr Sci, Fisheries Res Inst, Anhui Key Lab Aquaculture & Stock Enhancement, Hefei 230031, Peoples R China
关键词： microcystin-LR; subchronic exposure; environmentally relevant concentration; hepatic inflammation; oxidative stress; lipid metabolic disorders
期刊名称：TOXINS （ 影响因子：4.0； 五年影响因子：4.5 ）
ISSN：
年卷期： 2025 年 17 卷 6 期
页码：
收录情况： SCI
摘要： Microcystin-leucine arginine (MC-LR) is a prominent water pollutant known for its potent hepatic toxicity. However, the effects of subchronic exposure to environmentally relevant concentrations of MC-LR on the fish liver remain poorly understood. This study aimed to systematically evaluate the impact of subchronic MC-LR exposure on the liver of darkbarbel catfish (Tachysurus vachelli). A total of 270 one-year-old fish were exposed to MC-LR (0, 2, and 5 mu g/L) for 28 days and sampled on days 14 (D14) and 28 (D28). Histopathological analysis revealed marked hepatic inflammation in the MC-LR treatment groups, manifested as cellular degeneration, hyperemia, and inflammation. MC-LR exposure induced oxidative stress, evidenced by elevated malondialdehyde (MDA) levels and compensatory upregulation of superoxide dismutase (SOD) activity on D28. While hepatic lipid profiles were not altered by low-dose MC-LR, significant elevation of low-density lipoprotein cholesterol (LDL-C) specifically on D28 indicated incipient lipid metabolic disorder. Metabolomic analysis demonstrated a higher sensitivity, highlighting the stress response of the liver to low-dose MC-LR exposure. The results suggest MC-LR exposure disrupted hepatic phosphatidylcholine (PC) biosynthesis and inhibited lipoprotein formation, thereby impairing lipid transport and contributing to lipid metabolic disorders. In summary, subchronic exposure to environmentally relevant concentrations of MC-LR-induced hepatic tissue inflammation, oxidative stress, and lipid metabolic disorders in darkbarbel catfish.
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