Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway
文献类型： 外文期刊
作者： Wang, Chenlong 1 ; Wang, Mengya 1 ; Yang, Yueru 1 ; Chen, Chuangjiang 1 ; Rahman, Sajid Ur 1 ; Yang, Zhiping 2 ; Ding, Hongyan 3 ; Huang, Wanyue 1 ; Wang, Xichun 1 ;
作者机构： 1.Anhui Agr Univ, Coll Vet Med, Hefei 230061, Peoples R China
2.Huangyuan Cty Anim Husb & Vet Stn, Xining 812100, Qinghai, Peoples R China
3.Anhui Acad Agr Sci, Inst Anim Sci & Vet Med, Anhui Prov Key Lab Livestock & Poultry Prod Safety, Hefei 230031, Peoples R China
4.Anhui Prov Engn Lab Anim Food Qual & Biosafety, Hefei 230036, Peoples R China
关键词： zearalenone; rutin; porcine endometrial stromalcells; oxidative stress; cell damage
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 50 期
页码：
收录情况： SCI
摘要： Zearalenone (ZEA) induces oxidative damage in porcine endometrial stromal cells (ESCs), which is a critical factor affecting the growth and reproduction of female pigs. We hypothesize that rutin, a flavonoid antioxidant, can alleviate ZEA-induced cellular damage through the p53 signaling pathway. In this experiment, porcine ESCs were used as a research model. After transfection with siRNA to silence the p53 gene, rutin and ZEA were added to the cocultured porcine ESCs. Rutin notably reduced the ZEA-induced apoptosis rate, ROS, MDA, and 4-HNE levels via the p53 pathway; lowered the expression of LC3, Beclin-1, p62, Bax, and CHOP; and significantly improved cell viability, GSH-Px, T-SOD enzyme activity, and Bcl-2 expression. It also inhibited both apoptosis and autophagy. These findings suggested a novel antioxidant mechanism by which rutin mitigated the toxic effects of ZEA, highlighting the role of the p53 gene knockdown in this process.
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