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Identification of Signatures of Selection by Whole-Genome Resequencing of a Chinese Native Pig

文献类型： 外文期刊

作者： Zhang, Wei 1 ; Yang, Min 2 ; Zhou, Mei 1 ; Wang, Yuanlang 2 ; Wu, Xudong 2 ; Zhang, Xiaodong 2 ; Ding, Yueyun 2 ; Zhao, G 1 ;

作者机构： 1.Anhui Acad Agr Sci, Anhui Prov Key Lab Livestock & Poultry Prod Safet, Inst Anim Husb & Vet Med, Key Lab Pig Mol Quantitat Genet, Hefei, Peoples R China

2.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei, Peoples R China

3.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming, Yunnan, Peoples R China

关键词： Anqing six-end-white pig; SNP; signatures of selection; F-ST; theta pi

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Identification of genomic signatures of selection that help reveal genetic mechanisms underlying traits in domesticated pigs is of importance. Anqing six-end-white pig (ASP), a representative of the native breeds in China, has many distinguishing phenotypic characteristics. To identify the genomic signatures of selection of the ASP, whole-genome sequencing of 20 ASPs produced 469.01 Gb of sequence data and more than 26 million single-nucleotide polymorphisms. Combining these data with the available whole genomes of 13 Chinese wild boars, 157 selected regions harboring 48 protein-coding genes were identified by applying the polymorphism levels (theta pi) and genetic differentiation (F-ST) based cross approaches. The genes found to be positively selected in ASP are involved in crucial biological processes such as coat color (MC1R), salivary secretion (STATH), reproduction (SPIRE2,OSBP2,LIMK2,FANCA, andCABS1), olfactory transduction (OR5K4), and growth (NPY1R,NPY5R, andSELENOM). Our research increased the knowledge of ASP phenotype-related genes and help to improve our understanding of the underlying biological mechanisms and provide valuable genetic resources that enable effective use of pigs in agricultural production.

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