文献类型： 外文期刊
作者： Yang, Zheng 2 ; Chen, Yangyang 3 ; Ma, Shijie 4 ; Zhang, Meng 3 ; Tang, Tong 5 ; Du, Chang 1 ;
作者机构： 1.South China Normal Univ, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Peoples R China
2.Zhengzhou Univ, Sch Agr Sci, Natl Key Lab Cotton Biobreeding & Integrated Utili, Zhengzhou Res Base, Zhengzhou 450001, Henan, Peoples R China
3.Northwest A&F Univ, Coll Agron, Yangling 712100, Shaanxi, Peoples R China
4.Anhui Acad Agr Sci, Crop Res Inst, Hefei 230031, Anhui, Peoples R China
5.Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Chengdu, Peoples R China
关键词： Brassica; Camelina sativa; Oilseeds; Fatty acid bioengineering; Long-chain polyunsaturated fatty acids (LC-PUFAs); Very-long-chain polyunsaturated fatty acids (VLC-PUFAs)
期刊名称：PROGRESS IN LIPID RESEARCH （ 影响因子：14.9； 五年影响因子：16.5 ）
ISSN： 0163-7827
年卷期： 2025 年 99 卷
页码：
收录情况： SCI
摘要： Long-chain polyunsaturated fatty acids (LC-PUFAs), especially very long-chain polyunsaturated fatty acids (VLCPUFAs), are highly beneficial to human health including brain development, cardiovascular health and the immune system. Plant-derived edible oils serve as crucial dietary sources of PUFAs for humans. However, oilseed crops such as soybean, peanut, rapeseed, sesame and flax, generally contain insufficient content of LC-PUFAs and do not naturally produce VLC-PUFAs. This review discusses PUFA biosynthesis, current efforts on LC-PUFA bioengineering in oilseed crops, comparing the advantages of different genetic engineering strategies and highlights the bottlenecks encountered in this field. Combination of high-efficient enzymes from various species has enabled the improvement of LC-PUFAs and slight production of VLC-PUFAs, though under risk of generational instability. These and future intelligently designed enzymes with multidisciplinary approaches in molecular biology, biochemistry and plant physiology can be crucial in developing oilseed crops that meet the growing demand for LC-PUFAs.
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