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Evaluating Salmonella pullorum dissemination and shedding patterns and antibody production in infected chickens

文献类型： 外文期刊

作者： Shen, Xuehuai 1 ; Zhang, Anyun 3 ; Gu, Ju 3 ; Zhao, Ruihong 1 ; Pan, Xiaocheng 1 ; Dai, Yin 1 ; Yin, Lei 1 ; Zhang, Qinghe 1 ; Hu, Xiaomiao 1 ; Wang, Hongning 3 ; Zhang, Danjun 1 ;

作者机构： 1.Anhui Acad Agr Sci, Livestock & Poultry Epidem Dis Res Ctr Anhui Prov, Inst Anim & Vet Sci, Hefei 230031, Peoples R China

2.Anhui Prov Key Lab Livestock & Poultry Product Sa, 40 Nongkenan RD, Hefei 230031, Anhui, Peoples R China

3.Sichuan Univ, Coll Life Sci, Anim Dis Prevent & Food Safety Key Lab Sichuan Pr, Key Lab Bioresource & Ecoenvironm,Minist Educ, Chengdu 610064, Peoples R China

关键词： Salmonella pullorum; chickens; organ dissemination pattern; bacterial shedding; serum antibody; pullorum disease; horizontal transmission

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.792； 五年影响因子：3.008 ）

ISSN：

年卷期： 2022 年 18 卷 1 期

页码：

收录情况： SCI

摘要： Background Pullorum disease caused by Salmonella pullorum is one of the most important infectious diseases in the poultry industry, responsible for causing substantial economic losses globally. On farms, the traditional method to detect S. pullorum infection mainly involves the collection of feces and sera to test for antigens and antibodies, respectively, but the regularity of Salmonella pullorum dissemination in internal organs and shedding patterns and antibody production in infected chickens remains unclear. Herein we aimed to investigate the dissemination of S. pullorum to different organs and bacterial shedding patterns in the faeces as well as serum antibody production post-infection in chickens of different ages. Result In this study, the liver and heart of 2-day-old chickens showed the highest copy numbers of S. pullorum at 6.4 x 10(6) and 1.9 x 10(6) copies of DNA target sequences/30 mg, respectively. In case of 10-day-old chickens, the percentage of S. pullorum fecal shedding (0%-40%) and antibody production (0%-56.6%) markedly fluctuated during the entire experiment; furthermore, in case of 42-week-old chickens, the percentage of birds showing S. pullorum shedding in the faeces showed a downward trend (from 63.33% to 6.6% in the oral inoculation group and from 43.3% to 10% in the intraperitoneal injection group), while that of birds showing serum antibody production remained at a high level (38.3% and 80% in the oral inoculation and intraperitoneal injection groups, respectively). We also performed cohabitation experiments, showed that 15% 10-day-old and 3.33% 42-week-old chickens were infected via the horizontal transmission in cohabitation with S. pullorum infected chickens, and revealed a high risk of horizontal transmission of S. pullorum. Conclusion This study systematically evaluated the dissemination of S. pullorum in internal organs and bacterial fecal shedding patterns, and antibody production in infected chickens. Collectively, our findings indicate how to effectively screen S. pullorum-negative chickens on livestock farms and should also help in the development of measures to control and eradicate S. pullorum.

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