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"Dandelion" magnetic bead-driven CDs@CeO2 based-multifunctional nanoplatform for tri-modal ultrasensitive detection and efficient eradication of pathogenic bacteria

文献类型： 外文期刊

作者： Zhan, Ying 1 ; Li, Hui 1 ; Ren, Yuwei 1 ; Wang, Yang 1 ; Jiao, Rui 1 ; Zhang, Xiyan 1 ; Yu, Xiaoyu 1 ; Zhang, Xin 1 ; Cheng, Jianghua 2 ; Ye, Yingwang 1 ;

作者机构： 1.Hefei Univ Technol, Engn Res Ctr Bioproc, Key Lab Anim Food Green Mfg & Resource Min Anhui P, Sch Food & Biol Engn,Minist Educ, Hefei 230009, Peoples R China

2.Inst Agroprod Proc, Anhui Acad Agr Sci, Anhui Engn Lab Food Microbial Fermentat & Funct Ap, Hefei 230036, Peoples R China

关键词： CeO 2 doped with carbon dots; Dandelion magnetic beads; Multi-modal detection; Enhanced sterilization

期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：7.7； 五年影响因子：7.4 ）

ISSN：

年卷期： 2025 年 424 卷

页码：

收录情况： SCI

摘要： To address the challenge of foodborne pathogens, we have developed an ultra-sensitive tri-modal detection and effective pathogen eradication strategy utilizing a "dandelion" magnetic bead-driven cerium dioxide doped with carbon dots (CDs@CeO2) multifunctional nanoplatform. Aptamer (Apt) modification CDs@CeO2 specifically recognizes and binds to the outer membrane proteins of Salmonella typhimurium (S. typhimurium). Concurrently, mannose-functionalized dandelion-like magnetic beads selectively recognize adhesins of S. typhimurium, avoiding competition with Apt for binding sites and leveraging the strong bacterial capture capability for highsensitivity detection. The prepared CDs@CeO2 has been demonstrated to exhibit favourable fluorescence characteristics. In the presence of H2O2, CDs@CeO2 is capable of oxidising colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) into blue oxide, displaying exceptional photothermal properties. CDs@CeO2 have the potential to generate center dot OH through a Fenton-like reaction, which could directly damage cells. Notably, coupling the photosensitizer Ce6 to CDs@CeO2 and subsequent illumination generates 1O2, which synergistically eradicates bacteria with center dot OH. Detection limits of the fluorescence, colorimetry, and photothermal methods were 3.85 cfu/mL, 9.44 cfu/mL, and 5.00 cfu/mL, respectively. The platform successfully achieves precise detection of S. typhimurium in actual pre-prepared food samples through fluorescence, colorimetry, and photothermal tri-modal signals, and effectively kills bacteria, achieving trace detection and source control.

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