文献类型： 外文期刊

作者： Yang, Hao ¹ ; Fu, Hongwei ¹ ; Zhao, Yutong ¹ ; Li, Run ¹ ; Cao, Man ¹ ; Liu, Yi ¹ ; Ni, Yachao ¹ ; Song, Wei ⁴ ; Liang, Yangyang ⁵ ; Cai, Panyuan ¹ ; Chang, Wei ¹ ; Tao, Fangbiao ¹ ; Wang, Hua ¹ ; Liu, Kaiyong ¹ ;

作者机构： 1.Anhui Med Univ, Ctr Big Data & Populat Hlth IHM, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China

2.Anhui Med Univ, Key Lab Populat Hlth Life Cycle, Minist Educ Peoples Republ China, Hefei 230032, Anhui, Peoples R China

3.Anhui Med Univ, Key Lab Environm Toxicol, Anhui Higher Educ Inst, Hefei 230032, Anhui, Peoples R China

4.Anhui Med Univ, Anhui Prov Key Lab Environm, Populat Hlth Life Course, Hefei 230032, Anhui, Peoples R China

5.Technol Ctr Hefei Customs, Anhui Prov Key Lab Anal & Detect Food Safety, Hefei 230022, Anhui, Peoples R China

6.Anhui Acad Agr Sci, Fisheries Res Inst, Key Lab Freshwater Aquaculture & Enhancement Anhui, Hefei 230001, Anhui, Peoples R China

关键词： Metagenomics; ARGs; Pesticides; PPCPs; Chaohu Lake; Metagenomics; ARGs; Pesticides; PPCPs; Chaohu Lake

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2025 年 497 卷

页码：

收录情况： SCI

摘要： This study explored the spatiotemporal distributions of microorganisms and antibiotic resistance genes (ARGs) in the surface water, sediments, and fish intestinal contents (IC) of Chaohu Lake, and further revealed the pharmaceuticals and personal care products (PPCPs), pesticides in lake water and their relationships with ARGs. 53 types of pesticides and 25 types of PPCPs were identified in the river-lake system basin, with the highest concentrations observed for tebuconazole (1142.36 ng/L) and amantadine (851.41 ng/L). Higher concentrations of these target contaminants were detected in the western part of the lake and during the wet season. No significant east-west differences in ARGs and microbiota across the three environmental matrices were found, whereas seasonal variations impacted lake water and IC more profoundly than sediments. Significant correlations be-tween microbiota and ARGs in the lake water and IC, while those in sediments showed weaker associations. Co-occurrence network analysis showed, among three environmental media, beta-lactam and multidrug-resistant genes were widespread found, and Proteobacteria were identified as a stable host. Non-antibiotic pollutants, such as amantadine and terbuthylazine, displayed significant positive correlations with ARGs, similar to sulfamethox-azole and clindamycin. Our findings highlight the important roles of seasonal hydrological changes and non-antibiotic pollutants in the dissemination of ARGs.