Simultaneous determination of enantiomers of carfentrazone-ethyl and its metabolite in eight matrices using high-performance liquid chromatography with tandem mass spectrometry
文献类型： 外文期刊
作者： Duan, Jinsheng 1 ; Dong, Xu 2 ; Shen, Yang 2 ; Gao, Beibei 1 ; Zhang, Zhaoxian 1 ; Gao, Tongchun 3 ; Wang, Minghua 1 ;
作者机构： 1.Nanjing Agr Univ, Dept Pesticide Sci, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
2.Anhui Acad Agr Sci, Inst Plant Protect & Agroprod Safety, Key Lab Agroprod Safety Risk Evaluat Hefei, Hefei, Anhui, Peoples R China
3.Anhui Acad Agr Sci, Inst Plant Protect & Agroprod Saf
关键词： absolute configuration; carfentrazone-ethyl; chirality; enantioseparation; metabolite
期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）
ISSN： 1615-9306
年卷期： 2018 年 41 卷 19 期
页码：
收录情况： SCI
摘要： A reversed-phase simultaneous determination method for the enantiomers of carfentrazone-ethyl and its metabolite carfentrazone in agricultural and environmental samples was established using high-performance liquid chromatography-tandem mass spectrometry. A complete enantioseparation of carfentrazone-ethyl and its chiral metabolite carfentrazone enantiomers was obtained using a chiral column. The absolute configuration and specific optical rotation of carfentrazone-ethyl and carfentrazone enantiomers were first confirmed as peaks 1, 2, 3, and 4: S-(+)-carfentrazone, R-(-)-carfentrazone, S-(-)-carfentrazone-ethyl, and R-(+)-carfentrazone-ethyl, respectively. The specificity, matrix effect, linearity, precision, accuracy, and stability were surveyed to evaluate the feasibility of the method. The mean recovery was in the range of 77.5-102.8% with relative standard deviations of 0.4-9.8% for the samples. The limits of detection of the enantiomers were evaluated as 0.7 to 6.0 g/kg, and the limits of quantification were 2.5 to 20 g/kg. The stereoselective degradation of carfentrazone-ethyl and carfentrazone in rice plant was investigated, and there was no clear enantioselectivity for carfentrazone-ethyl. As for carfentrazone, the enantiomer fractions value reached 0.85 at 7 days after spraying. The developed method was simple and reliable enough for the corresponding risk assessment of carfentrazone-ethyl and its metabolite enantiomers in crop plants, cereal grains, and soil samples.
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