文献类型： 外文期刊
作者： Li, Fangyu 1 ; Cai, Cuicui 1 ; Qu, Kaixing 2 ; Liu, Jianyong 2 ; Jia, Yutang 3 ; Hanif, Quratulain 4 ; Chen, Ningbo 1 ; Z 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
2.Yunnan Acad Grassland & Anim Sci, Kunming 650212, Yunnan, Peoples R China
3.Anhui Acad Agr Sci, Inst Anim Sci & Vet Med, Hefei, Peoples R China
4.Pakistan Inst Engn & Appl Sci, Natl Inst Biotechnol & Genet Engn, Faisalabad, Pakistan
关键词： Cattle; DGAT1; K232A polymorphism; milk production traits
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： The production traits of cattle, especially milk trait, are of great significance to human life. A quantitative trait loci (QTL) associated with milk fat content was detected in the centromeric region of cattle chromosome 14. This QTL harbors a strong candidate gene called DGAT1 responsible for the milk quality. A non-conservative substitution of lysine by alanine (K232A) was found in DGAT1 gene producing a strong effect on milk composition and yield. The lysine (K allele) is associated with increased milk fat content, while the decreased milk fat content is linked to the alanine (A allele) amino acid. To estimate the frequencies of the DGAT1 K232A polymorphism in Chinese cattle breeds, PCR and DNA sequencing methods were used to investigate the polymorphism of DGAT1 K232A in a total of 682 individuals, including 655 Chinese cattle and 27 Holstein cattle. The results demonstrated that the frequency of K allele gradually elevated from the northern group to the southern group of native Chinese cattle, whereas the frequency of A allele showed a contrary pattern, displaying a significant geographical difference across native Chinese cattle breeds. Our results confirm that the southern cattle group has higher milk fat content than that of the northern group.
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