Polymorphisms of the Growth Hormone Releasing Hormone Receptor Gene Affect Body Conformation Traits in Chinese Dabieshan Cattle
文献类型： 外文期刊
作者： Zhao, Shuanping 1 ; Jin, Hai 1 ; Xu, Lei 1 ; Jia, Yutang 1 ;
作者机构： 1.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Anhui Prov Key Lab Livestock & Poultry Prod Safet, Hefei 230031, Peoples R China
关键词： growth hormone-releasing hormone receptor gene; Chinese Dabieshan cattle; body conformation traits; association analysis
期刊名称：ANIMALS （ 影响因子：3.231； 五年影响因子：3.312 ）
ISSN： 2076-2615
年卷期： 2022 年 12 卷 13 期
页码：
收录情况： SCI
摘要： Simple Summary Increasing growth traits can impact the economic benefit of livestock. Polymorphisms can offer us potential molecular markers for the growth traits of cattle, and provide a reference for cultivating an improved cattle population according to the markers in the future. In this study, the growth hormone-releasing hormone receptor gene polymorphism is significantly associated with the body conformation traits of Chinese Dabieshan cattle, and it could be used as a candidate genetic marker for body conformation trait selection in cattle. This study further verified that the GHRHR gene plays a vital role in Chinese cattle, and provides a data basis for the research and improvement of cattle breeding programs in China. This study was performed to expose the polymorphisms of the growth hormone-releasing hormone receptor gene in Chinese Dabieshan cattle, evaluate its effect on body conformation traits, and find potential molecular markers in Chinese cattle. The GHRHR structure and the phylogenetic tree were analyzed using bioinformatics software. The polymorphism of the GHRHR gene in 486 female cattle was genotyped by PCR-RFLP and DNA sequencing, and the association between SNPs and body conformation traits of Chinese Dabieshan cattle was analyzed by one-way ANOVA in SPSS software. GHRHR was often conserved in nine species, and its sequence of cattle was closest to sheep and goats. Six polymorphic SNPs were identified, g.10667A > C and g.10670A > C were missense mutation. The association analysis indicated that the six SNPs significantly influenced the body conformation traits of Chinese Dabieshan cattle (p < 0.05). Six haplotypes were identified and Hap1 (-CAACGA-) had the highest frequency (36.10%). The Hap3/5 (-GCCCCCGGAAGG-) exhibited a significantly greater wither height (WH), hip height (HH), heart girth (HG), and hip width (HW) (p < 0.05). Overall, the polymorphisms of GHRHR affected the body conformation traits of Chinese Dabieshan cattle, and the GHRHR gene could be used as a molecular marker in Dabieshan cattle breeding programs.
- 相关文献
作者其他论文 更多>>
-
High-Performance Detection of Mycobacterium bovis in Milk Using Recombinase-Aided Amplification-Clustered Regularly Interspaced Short Palindromic Repeat-Cas13a-Lateral Flow Detection
作者：Wang, Jieru;Zeng, Xiaoyu;Yin, Dongdong;Gou, Jiaojiao;Pan, Xiaocheng;Wang, Nan;Xu, Lei;Cheng, Junsheng;Zhang, Xiaoqian;Zhang, Yinghui;Zhu, Xiaojie
关键词：milk; food safety; bovine tuberculosis; CRISPR-Cas13a; rapid detection
-
Estimation of Linkage Disequilibrium, Effective Population Size, and Genetic Parameters of Phenotypic Traits in Dabieshan Cattle
作者：Jin, Hai;Zhao, Shuanping;Jia, Yutang;Xu, Lei
关键词：Dabieshan cattle; linkage disequilibrium; effective population size; heritability
-
Transcriptome Analysis of Bovine Rumen Tissue in Three Developmental Stages
作者：Zhang, Yapeng;Cai, Wentao;Li, Qian;Wang, Yahui;Wang, Zezhao;Zhang, Qi;Xu, Lingyang;Xu, Lei;Hu, Xin;Zhu, Bo;Gao, Xue;Chen, Yan;Gao, Huijiang;Li, Junya;Zhang, Lupei;Xu, Lei
关键词：rumen development; carcass traits; beef cattle; transcriptome; GWAS enrichment analysis
-
Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing
作者：Guan, Xiwen;Zhao, Shuanping;Jin, Hai;Jia, Yutang;Xu, Lei;Guan, Xiwen;Chen, Ningbo;Lei, Chuzhao;Xiang, Weixuan
关键词：whole-genome sequencing; population structure; diversity; genetic signatures; indigenous cattle breeds
-
Genetic variants of the growth differentiation factor 8 affect body conformation traits in Chinese Dabieshan cattle
作者：Zhao, Shuanping;Jin, Hai;Xu, Lei;Jia, Yutang
关键词：Association Analysis; Body Conformation Traits; Chinese Dabieshan Cattle; Growth Differentiation Factor 8 Gene
-
An Analysis of Natural Variation Reveals That OsFLA2 Controls Flag Leaf Angle in Rice (Oryza sativa L.)
作者：Jiang, Jianhua;Hu, Changmin;Xu, Lei;Zhang, Ying;Wang, Dezheng;Dang, Xiaojing;Zhang, Yuanqing;Hong, Delin;Li, Yulong
关键词：genome-wide association mapping; hybrid seed production; natural variation; OsFLA2; rice
-
Genetic analysis and QTLs identification of stigma traits in japonica rice (Oryza sativa L.)
作者：Jiang, Jianhua;Xu, Lei;Hu, Changmin;Zhang, Ying;Wang, Dezheng;Dang, Xiaojing;Xiao, Meihua
关键词：Favorable alleles; F-1 hybrid seed production; Long stigma; Major gene plus polygene model; Rice
