FgRad50 Regulates Fungal Development, Pathogenicity, Cell Wall Integrity and the DNA Damage Response in Fusarium graminearum
文献类型： 外文期刊
作者： Zhang, Chengqi 1 ; Ren, Xuexiang 2 ; Wang, Xintong 1 ; Wan, Qiong 1 ; Ding, Kejian 1 ; Chen, Li 1 ;
作者机构： 1.Anhui Agr Univ, Key Lab Biol & Sustainable Management Plant Dis &, Anhui Higher Educ Inst, Coll Plant Protect, Hefei, Peoples R China
2.Anhui Acad Agr Sci, Inst Plant Protect & Agroprod Safety, Hefei, Peoples R China
关键词： Fusarium graminearum; FgRad50; fungal growth and virulence; deoxynivalenol; cell wall integrity; DNA damage response
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN： 1664-302X
年卷期： 2020 年 10 卷
页码：
收录情况： SCI
摘要： Rad50 is a member of the double strand break repair epistasis group of proteins that play important roles in regulating DNA damage checkpoint signaling, telomere maintenance, homologous recombination and non-homologous end-joining in eukaryotes. However, the function of Rad50 in fungal plant pathogens remains unknown. In this study, we report the functional investigation of FgRad50 in the wheat head blight pathogen Fusarium graminearum. FgRad50 is an ortholog of Saccharomyces cerevisiae Rad50 that could restore the sensitivity of the yeast Rad50 mutant to DNA damage agents. The FgRad50 deletion mutant (Delta FgRad50) exhibited defective vegetative growth, asexual/sexual development and virulence, as well as disrupted deoxynivalenol biosynthesis. Moreover, deletion of FgRad50 resulted in hypersensitivity to DNA damage agents. Unexpectedly, FgRad50 plays a key role in responses to cell wall-damaging agents by negatively regulating phosphorylation of FgMgv1, a MAP kinase in the cell wall integrity (CWI) pathway. Taken together, these results suggest that FgRad50 plays critical roles in fungal development, virulence and secondary metabolism in F. graminearum, as well as CWI and the DNA damage response.
- 相关文献
作者其他论文 更多>>
-
Development and application of a novel suspension concentrate for seed coating of rice for controlling bakanae disease and seedling rot disease
作者：Ren, Xue-Xiang;Yu-Chi;Zhao-Li;Su, Xian-Yan;Ye, Zheng-He;Chen, Li;Shun-He
关键词：bakanae disease; control effect; Fusarium moniliforme Sheldon; suspension concentrate for seed coating of rice; nonionic surfactants security
-
Rhizobium Soaking Promoted Maize Growth by Altering Rhizosphere Microbiomes and Associated Functional Genes
作者：Li, Zhao;Chi, Yu;Su, Xianyan;Ye, Zhenghe;Ren, Xuexiang
关键词：Bradyrhizobium japonicum; growth; gene expression; soil microorganism; Zea mays
-
Editing of rice (Oryza sativa L.) OsMKK3 gene using CRISPR/Cas9 decreases grain length by modulating the expression of photosystem components
作者：Qing, Dongjin;Chen, Weiwei;Li, Jingcheng;Pan, Yinghua;Zhou, Weiyong;Liang, Qiongyue;Yuan, Jinghua;Gan, Dongmei;Chen, Li;Chen, Lei;Huang, Juan;Dai, Gaoxing;Deng, Guofu;Huang, Suosheng;Zhou, Yan;Zhou, Yan;Dai, Gaoxing;Deng, Guofu
关键词：CRISPR; Cas9; grain size; mutant; OsMKK3; proteomics; regulated protein
-
The Pythium periplocum elicitin PpEli2 confers broad-spectrum disease resistance by triggering a novel receptor-dependent immune pathway in plants
作者：Yang, Kun;Wang, Yi;Li, Jialu;Du, Yaxin;Liang, Dong;Shen, Danyu;Jing, Maofeng;Dou, Daolong;Zhai, Ying;Peng, Hao;Ji, Rui;Ren, Xuexiang;Dou, Daolong
关键词：
-
miRNA novel_268 targeting NlABCG3 is involved in nitenpyram and clothianidin resistance in Nilaparvata lugens
作者：Li, Zhao;Ren, Xuexiang;Li, Zhao;Mao, Kaikai;Jin, Ruoheng;Cai, Tingwei;Qin, Yao;Zhang, Yunhua;He, Shun;Ma, Kangsheng;Wan, Hu;Li, Jianhong
关键词：NlABCG3; miRNA; Gene expression; Resistance; Nilaparvata lugens
-
Sensitive, simultaneous and quantitative detection of deoxynivalenol and fumonisin B-1 in the water environment using lateral flow immunoassay integrated with smartphone
作者：Feng, Jiankun;Wang, Xinwei;Liu, Zhenjiang;Xue, Yuan;Song, Qingsong;Wang, Baojian;Ren, Xuexiang;Zhang, Leigang
关键词：Smartphone; Lateral flow immunoassay; Deoxynivalenol; Fumonisin B-1; Water environment
-
Thifluzamide, Fludioxonil, and Clothianidin as Seed Treatment Can Efficiently Control Major Soil-Borne Diseases, Aphids (Aphidoidea spp.), and Residue Distribution in the Field
作者：Chen, Chao;Wang, Xumiao;Yin, Shanshan;Wang, Chao;Gao, Quan;Cao, Haiqun;Ren, Xuexiang
关键词：seed treatment; wheat sharp eyespot; aphids; earthworms; pesticide
