文献类型： 外文期刊
作者： Jiang, Yao 1 ; Zou, Quan 1 ; Liu, Bo 3 ; Li, Shujuan 1 ; Wang, Yi 1 ; Liu, Tianlong 3 ; Ding, Xiangdong 1 ;
作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Minist Agr,Lab Anim Genet Breeding & Reprod, Beijing, Peoples R China
2.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Hefei, Peoples R China
3.China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol, Minist Agr, Beijing, Peoples R China
关键词： pig; hair follicle; hair types; morphogenesis development; animal model
期刊名称：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY （ 影响因子：6.684； 五年影响因子：7.219 ）
ISSN： 2296-634X
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： The pig is an increasingly popular biomedical model, but only a few in depth data exist on its studies in hair follicle (HF) morphogenesis and development. Hence, the objective of this study was to identify the suitability of the pig as an animal model for human hair research. We performed a classification of pig HF morphogenesis stages and hair types. All four different hair types sampled from 17 different body parts in pig were similar to those of human. The Guard_2 sub-type was more similar to type II human scalp hair while Guard_1, Awl, Auchene, and Zigzag were similar to type I scalp hair. Based on morphological observation and marker gene expression of HF at 11 different embryonic days and six postnatal days, we classified pig HF morphogenesis development from E41 to P45 into three main periods - induction (E37-E41), organogenesis (E41-E85), and cytodifferentiation (>E85). Furthermore, we demonstrated that human and pig share high similarities in HF morphogenesis occurrence time (early/mid gestational) and marker gene expression patterns. Our findings will facilitate the study of human follicle morphogenesis and research on complex hair diseases and offer researchers a suitable model for human hair research.
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