文献类型： 外文期刊

作者： Zhang, Wen-Jing ¹ ; Cheng, Jiang-Hua ³ ; Nie, Zheng-Chao ¹ ; Ding, Bang-Sheng ¹ ; Han, Zhong ⁴ ; Zheng, Wei-Wei ¹ ;

作者机构： 1.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Dept Clin Lab,USTC, Hefei 230001, Anhui, Peoples R China

2.Natl Clin Res Ctr Lab Med, Core Unit, Hefei, Anhui, Peoples R China

3.Anhui Acad Agr Sci, Inst Agr Prod Proc, Hefei, Anhui, Peoples R China

4.Shengzhou Peoples Hosp, Dept Clin Lab, Shengzhou 312400, Zhejiang, Peoples R China

关键词： E-selectin; gene polymorphism; diabetes; Chinese

期刊名称：CLINICAL LABORATORY （ 影响因子：1.053； 五年影响因子：1.101 ）

ISSN： 1433-6510

年卷期：

页码：

收录情况： SCI

摘要： Background: Diabetes is associated with endothelial cell dysfunction. E-selectin is an endothelial cell adhesion molecule, which is bound for endothelial cell activation. E-selectin gene+A561C polymorphism is associated with many different disorders: essential hypertension, stroke, angina pectoris, coronary heart disease, etc. But the association with type 2 diabetes remains unclear. Therefore, we aimed to investigate the role of E-selectin gene+A561C polymorphism and soluble E-selectin in type 2 diabetes in a Chinese population. Methods: This study involved 317 patients with type 2 diabetes and 285 normal healthy controls. Genotyping of Eselectin gene+A561C polymorphism was examined by polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP). Soluble E-selectin was examined by enzyme linked immunosorbent assay (ELISA). Biochemical markers were measured by Roche 7600 Automated Biochemical Analyzer. Results: We found that C allele frequency in E-selectin A561 C polymorphism of Chinese T2DM group was higher than control group. The level of soluble E-selectin in T2DM group was higher than control group. TC, TG, LDLC, ApoB, and sE-selectin (soluble E-selectin) in AC and CC genotypes were higher than AA genotype. Conclusions: Our findings showed that E-selectin +A561C polymorphism was correlated in the Chinese population with type 2 diabetes. C allele and soluble E-selectin may be predisposing factors of Chinese population with type 2 diabetes. (Clin. Lab. 2022;68:xx-xx. DOI: 10.7754/Clin.Lab.2021.211045)