文献类型： 外文期刊
作者： Huang, Long 1 ; Liu, Yu 2 ; Zhang, Xinxin 2 ; Xu, Jie 2 ; Dai, Lu 3 ; Dai, Lishang 2 ; Huang, Lehao 2 ;
作者机构： 1.Anhui Acad Agr Sci, Fishery Inst, Anhui Prov Key Lab Aquaculture & Stock Enhancement, Hefei 230031, Peoples R China
2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China
3.Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanjing 210029, Peoples R China
4.Nanjing Med Univ, Affiliated Stomatol Hosp, Outpatient Dept 4, Nanjing 210029, Peoples R China
关键词： Crustaceans; Peroxiredoxin; Antimicrobial immunity
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）
ISSN： 1050-4648
年卷期： 2023 年 138 卷
页码：
收录情况： SCI
摘要： Members of the peroxiredoxin family are involved in a wide variety of physiological processes, including the ability to combat the effects of oxidative stress and immune responses, among others. Here, we cloned the cDNA of Procambarus clarkii Peroxiredoxin 1 (designated as PcPrx-1) and investigated its biological role in immune system functions in relation to microbial pathogens. The PcPrx-1 cDNA had 744 base pairs in an open reading frame that encoded 247 amino acid residues and contained a PRX_Typ2cys domain. The analysis of tissue specific expression patterns revealed that PcPrx-1 expression was ubiquitous in all tissues. In addition, the mRNA transcript of PcPrx-1 was found to be highest in the hepatopancreas. There was a significant upregulation of PcPrx-1 gene transcripts after exposure to LPS, PGN, and Poly I:C, but the transcription patterns were different after pathogen challenge. Double-stranded RNA was used to knockdown PcPrx-1, which resulted in a striking change in the expression of all the tested P. clarkii immune-associated genes, including lectin, Toll, cactus, chitinase, phospholipase, and sptzale. On the whole, these results suggest that PcPrx-1 is important to confer innate immunity against pathogens by governing the expression of critical transcripts that encode immune -associated genes.
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