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Sub-chronically exposing zebrafish to environmental levels of methomyl induces dysbiosis and dysfunction of the gut microbiota

文献类型： 外文期刊

作者： Li, Mingxiao 1 ; Chen, Xi 1 ; Song, Chao 1 ; Fan, Limin 1 ; Qiu, Liping 2 ; Li, Dandan 2 ; Xu, Huimin 2 ; Meng, Shunlong 1 ; Mu, Xiyan 3 ; Xia, Bin 4 ; Ling, Jun 5 ;

作者机构： 1.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Sci Observing & Expt Stn Fishery Resources & Envir, Wuxi 214081, Peoples R China

3.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China

4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

5.Anhui Acad Agr Sci, Fisheries Inst, Hefei 230031, Peoples R China

关键词： Methomyl; 16S rRNA; Metabolism; Inflammation; Apoptosis; Danio rerio

期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：7.7； 五年影响因子：7.5 ）

ISSN： 0013-9351

年卷期： 2024 年 261 卷

页码：

收录情况： SCI

摘要： The widespread use of carbamate pesticides has led to numerous environmental and health concerns, including water contamination and perturbation of endocrine homeostasis among organisms. However, there remains a paucity of research elucidating the specific effects of methomyl on gut microbial composition and physiological functions. This study aimed to investigate the intricate relationship between changes in zebrafish bacterial communities and intestinal function after 56 days of sub-chronic methomyl exposure at environmentally relevant concentrations (0, 0.05, 0.10, and 0.20 mg/L). Our findings reveal significant methomyl-induced morphological changes in zebrafish intestines, characterized by villi shortening and breakage. Notably, methomyl exposure down-regulated nutrient and energy metabolism, and drug metabolism at 0.05-0.10 mg/L, while up-regulating cortisol, inflammation-related genes, and apoptotic markers at 0.20 mg/L. These manifestations indicate physiological stress imposition and disruption of gut microbiota equilibrium, impacting metabolic processes and instigating low-grade inflammatory responses and apoptotic cascades. Importantly, changes in intestinal function significantly correlated with shifts in specific bacterial taxa abundance, including Shewanella, Rubrobacter, Acinetobacter, Bacillus, Luteolibacter, Nocardia, Defluviimonas, and Bacteroides genus. In summary, our study underscores the potential adverse effects of environmental methomyl exposure on aquatic organisms, emphasizing the necessity for further research to mitigate its repercussions on environmental health and ecosystem stability.

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