A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
文献类型： 外文期刊
作者： Ruan, Ban-Feng 1 ; Guo, Qing-Lei 2 ; Li, Qing-Shan 2 ; Li, Lu-Zhi 1 ; Deora, Girdhar Singh 3 ; Zhou, Ben-Guo 4 ;
作者机构： 1.Hefei Univ, Key Lab Biofabricat Anhui Higher Educ, Hefei 230601, Peoples R China
2.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China
3.Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia
4.Anhui Acad Agr Sci, Inst Tobacoo Res, Hefei 230001, Peoples R China
关键词： Heterocyclic compounds; Oxadiazole; Anticancer; Antibacterial; Anti-inflammatory; SAR
期刊名称：CURRENT TOPICS IN MEDICINAL CHEMISTRY （ 影响因子：3.57； 五年影响因子：4.255 ）
ISSN： 1568-0266
年卷期： 2022 年 22 卷 7 期
页码：
收录情况： SCI
摘要： The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
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