文献类型： 外文期刊
作者： Fu, Lu 1 ; Jiang, Yao 1 ; Wang, Chonglong 2 ; Mei, Mengran 1 ; Zhou, Ziwen 1 ; Jiang, Yifan 1 ; Song, Hailiang 1 ; Ding, 1 ;
作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Lab Anim Genet Breeding & Reprod,Minist Agr, Beijing, Peoples R China
2.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Hefei, Peoples R China
关键词： genome-wide association study; feed efficiency; feed conversion ratio; average daily gain; average daily feed intake; residual feed intake
期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）
ISSN：
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： Feed efficiency (FE) traits in pigs are of utmost economic importance. Genetic improvement of FE related traits in pigs might significantly reduce production cost and energy consumption. Hence, our study aimed at identifying SNPs and candidate genes associated with FE related traits, including feed conversion ratio (FCR), average daily gain (ADG), average daily feed intake (ADFI), and residual feed intake (RFI). A genome-wide association study (GWAS) was performed for the four FE related traits in 296 Landrace pigs genotyped with PorcineSNP50 BeadChip. Two different single-trait methods, single SNP linear model GWAS (LM-GWAS) and single-step GWAS (ssGWAS), were implemented. Our results showed that the two methods showed high consistency with respect to SNP identification. A total of 32 common significant SNPs associated with the four FE related traits were identified. Bioinformatics analysis revealed eight common QTL regions, of which three QTL regions related to ADFI and RFI traits were overlapped. Gene ontology analysis revealed six common candidate genes (PRELID2, GPER1, PDX1, TEX2, PLCL2, ICAM2) relevant for the four FE related traits. These genes are involved in the processes of fat synthesis and decomposition, lipid transport process, insulin metabolism, among others. Our results provide, new insights into the genetic mechanisms and candidate function genes of FE related traits in pigs. However, further investigations to validate these results are warranted.
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