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Proteomic analysis of physiological function response to hot summer in liver from lactating dairy cows

文献类型： 外文期刊

作者： Wang, Qiangjun 1 ; Zhao, Xiaowei 1 ; Zhang, Zijun 2 ; Zhao, Huiling 1 ; Huang, Dongwei 1 ; Cheng, Guanglong 1 ; Yang, 1 ;

作者机构： 1.Anhui Acad Agr Sci, Inst Anim Sci & Vet Med, Hefei 230031, Peoples R China

2.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Peoples R China

关键词： Animal proteomics;Cow;Hot summer;Liver tissue;LC-MS/MS

期刊名称：JOURNAL OF THERMAL BIOLOGY （ 影响因子：2.902； 五年影响因子：3.102 ）

ISSN：

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收录情况： SCI

摘要： Lactation performance of dairy cattle is susceptible to heat stress. The liver is one of the most crucial organs affected by high temperature in dairy cows. However, the physiological adaption by the liver to hot summer conditions has not been well elucidated in lactating dairy cows. In the present study, proteomic analysis of the liver in dairy cows in spring and hot summer was performed using a label-free method. In total, 127 differentially expressed proteins were identified; most of the upregulated proteins were involved in protein metabolic processes and responses to stimuli, whereas most of the downregulated proteins were related to oxidation reduction. Pathway analysis indicated that 3 upregulated heat stress proteins (HSP90a, HSP90 beta, and endoplasmin) were enriched in the NOD-like receptor signaling pathway, whereas several downregulated NADH dehydrogenase proteins were involved in the oxidative phosphorylation pathway. The protein protein interaction network indicated that several upregulated HSP5 (HSP90a, HSP90 beta, and GRP78) were involved in more interactions than other proteins and were thus considered as central hub nodes. Our findings provide novel insights into the physiological adaption of liver function in lactating dairy cows to natural high temperature.

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