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Charge properties of peptides derived from casein affect their bioavailability and cytoprotection against H2O2-induced oxidative stress

文献类型： 外文期刊

作者： Wang, Bo 1 ; Xie, Ningning 2 ; Li, Bo 1 ;

作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

2.Anhui Acad Agr Sci, Inst Agrofood Sci & Technol, Hefei 230031, Peoples R China

3.Beijing Higher Inst Engn Res Ctr Anim Prod, Beijing 100083, Peoples R China

关键词： casein;charge property;antioxidative peptide;bioavailability;HepG-2 cells

期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.034； 五年影响因子：4.354 ）

ISSN：

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收录情况： SCI

摘要： The effects of charge properties of casein peptides on absorption stability, antioxidant activity, and cytoprotection were evaluated. Alcalase hydrolysates of casein were separated into 4 fractions by cation-exchange chromatography according to charge properties. After simulated digestion and Caco-2 cell transmembrane transport, we determined the total antioxidant capacity (Trolox equivalent antioxidative capacity and oxygen radical antioxidant activity) and nitrogen content of peptide fractions to estimate available antioxidant efficacy and bioavailability (BA) of peptides. Results showed that negatively charged peptide fractions had greater BA and antioxidant activities after digestion and absorption. The peptide permeates were used to test the cytoprotective effect against H2O2-induced oxidative damage in HepG-2 cells. All peptide permeates increased cell viability, elevated catalase activity, and decreased superoxide dismutase activity. However, negatively charged peptide fractions preserved cell viability to a greater degree. Therefore, the negatively charged peptides from casein may be potential antioxidants and could be used as ingredients in functional foods and dietary supplements.

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[1]Stability of casein antioxidant peptide fractions during in vitro digestion/Caco-2 cell model: characteristics of the resistant peptides. Xie, Ningning,Liu, Shanshan,Wang, Chan,Li, Bo,Xie, Ningning,Wang, Chan,Li, Bo.

[2]Hydrophobicity exerts different effects on bioavailability and stability of antioxidant peptide fractions from casein during simulated gastrointestinal digestion and Caco-2 cell absorption. Xie, Ningning,Wang, Bo,Jiang, Liangping,Liu, Congcong,Li, Bo,Xie, Ningning,Wang, Bo,Li, Bo,Jiang, Liangping,Liu, Congcong.

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