Charge properties of peptides derived from casein affect their bioavailability and cytoprotection against H2O2-induced oxidative stress
文献类型： 外文期刊
作者： Wang, Bo 1 ; Xie, Ningning 2 ; Li, Bo 1 ;
作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
2.Anhui Acad Agr Sci, Inst Agrofood Sci & Technol, Hefei 230031, Peoples R China
3.Beijing Higher Inst Engn Res Ctr Anim Prod, Beijing 100083, Peoples R China
关键词： casein;charge property;antioxidative peptide;bioavailability;HepG-2 cells
期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.034； 五年影响因子：4.354 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： The effects of charge properties of casein peptides on absorption stability, antioxidant activity, and cytoprotection were evaluated. Alcalase hydrolysates of casein were separated into 4 fractions by cation-exchange chromatography according to charge properties. After simulated digestion and Caco-2 cell transmembrane transport, we determined the total antioxidant capacity (Trolox equivalent antioxidative capacity and oxygen radical antioxidant activity) and nitrogen content of peptide fractions to estimate available antioxidant efficacy and bioavailability (BA) of peptides. Results showed that negatively charged peptide fractions had greater BA and antioxidant activities after digestion and absorption. The peptide permeates were used to test the cytoprotective effect against H2O2-induced oxidative damage in HepG-2 cells. All peptide permeates increased cell viability, elevated catalase activity, and decreased superoxide dismutase activity. However, negatively charged peptide fractions preserved cell viability to a greater degree. Therefore, the negatively charged peptides from casein may be potential antioxidants and could be used as ingredients in functional foods and dietary supplements.
- 相关文献
作者其他论文 更多>>
-
Oxygen Availability Governs the Mitigating Effect of 3,4-Dimethylpyrazole Phosphate on Nitrous Oxide Emissions from Paddy Soils under Various Water Managements
作者：Wang, Jun;Yang, Shuyun;Jin, Wenjun;Xie, Ningning;Che, Zhao;Zhang, Can;Li, Xiaoxiao;Wu, Gong;Dong, Zhaorong;Song, He
关键词：nitrous oxide; alternate wetting and drying; 3,4-dimethylpyrazol phosphate; oxygen availability; nitrification; denitrification
-
Enhancing the Textural Properties of Tibetan Pig Sausages via Zanthoxylum bungeanum Aqueous Extract: Polyphenol-Mediated Quality Improvements
作者：Huang, Jingjing;Wei, Haiqiu;Xie, Ningning;Huang, Jingjing;Wei, Haiqiu;Xie, Ningning;Luo, Zhang;Li, Liang;Liu, Zhendong
关键词：Zanthoxylum bungeanum; Tibetan pig; protein structure; texture; polyphenol; Chinese sausages; protein intermolecular force
-
Effects of starter culture inoculation on texture characteristics, flavor, and biogenic amine formation in slightly fermented beef
作者：Yang, Mingliu;Zhou, Yingqin;Huang, Jingjing;Zhang, Fusheng;Xie, Ningning;Yan, Yan;Zhou, Yingqin;Huang, Jingjing;Zhang, Fusheng;Xie, Ningning;Yan, Yan
关键词：Beef; Lactic acid bacteria; Fermentation; Quality characteristics; Biogenic amine; Flavor analysis
-
Optimizing preparation of low-NaCl protein gels from goose meat and understanding synergistic effects of pH/NaCl in improving gel characteristics
作者：Yan, Xinxin;Xie, Mingpeng;Li, Jingjun;Zheng, Haibo;Zhen, Zongyuan;Hu, Zhonghai;Xie, Ningning;Xie, Ningning;Zhen, Zongyuan;Zhen, Zongyuan
关键词：Gel properties; Salt-soluble protein; Low sodium; Response surface methodology; Synergistic analysis
-
Physicochemical characteristics and gel-forming properties of mandarin fish (Siniperca chuatsi) protein during the fish fermentation with Lactobacillus sake SMF-L5: The formation of garlic-cloves shaped protein gel
作者：Zhou, Yingqin;Yang, Mingliu;Yin, Junfeng;Huang, Jingjing;Yan, Yan;Zhang, Fusheng;Xie, Ningning;Zhou, Yingqin;Yin, Junfeng;Huang, Jingjing;Yan, Yan;Zhang, Fusheng;Xie, Ningning;Yang, Mingliu
关键词：Mandarin fish; Fermented fish; Physicochemical characteristic; Elastic texture; Pearson correlation
-
Responses of Soil Labile Organic Carbon on Aggregate Stability across Different Collapsing-Gully Erosion Positions from Acric Ferralsols of South China
作者：Tang, Xian;Li, Bo;Lu, Ying;Tang, Xian;Zhao, Jianrong;Wang, Hong;Alhaj Hamoud, Yousef;Shaghaleh, Hiba;Wang, Jiajia;Zhao, Tao
关键词：soil LOC; C pool management index; collapsing gully erosion; aggregate stability; Acric Ferralsols
-
A novel zinc-chelating peptide identified from rapeseed (Brassica napus) protein hydrolysate: insights into its zinc-binding sites by density functional theory
作者：Wang, Hao;Huang, Jingjing;Yang, Mingliu;Zhou, Yingqin;Yin, Junfeng;Yan, Yan;Xie, Ningning;Wang, Hao;Huang, Jingjing;Yang, Mingliu;Zhou, Yingqin;Yin, Junfeng;Yan, Yan;Xie, Ningning;Wang, Hao
关键词：Binding site; geometric structure; quantum chemistry; rapeseed protein; zinc chelating peptide
