文献类型： 外文期刊
作者： Chen, Lei 1 ; Zhu, Hualing 1 ; Yang, Song 1 ; Zhou, Beibei 1 ; You, Fenghui 1 ; Yan, Xiaoming 1 ;
作者机构： 1.Anhui Acad Agr Sci, Inst Agroprod Proc, Hefei 230031, Peoples R China
关键词： Biomaterials;Nanocrystalline materials;Silybin;Calcium phosphate;Drug delivery
期刊名称：MATERIALS LETTERS （ 影响因子：3.423； 五年影响因子：3.003 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Silybin, the main component of silymarin, has been widely used as a hepatoprotective agent for a variety of acute and chronic liver diseases. However, its poor aqueous solubility lead to poor oral absorption and low bioavailability, which strongly limit its applications. The amorphous calcium phosphate (ACP) nanosphere and hydroxyapatite (HAP) nanorod have been prepared and used for the investigation of the silybin loading and release. The results indicate that both ACP nanosphere and HAP nanorod have relatively high silybin-loading capacities which reach to 900 and 825 mg.g(-1). Moreover, the as-prepared silybin delivery systems exhibit sustained drug release performance in simulated gastric fluid and simulated intestinal fluid. (C) 2015 Elsevier B.V. All rights reserved.
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