您好，欢迎访问安徽省农业科学院 机构知识库！

Influences of chronic copper exposure on intestinal histology, antioxidative and immune status, and transcriptomic response in freshwater grouper (Acrossocheilus fasciatus)

文献类型： 外文期刊

作者： Wang, Lei 1 ; Wang, Bin 1 ; Hu, Cong 1 ; Wang, Chenyang 1 ; Gao, Chang 1 ; Jiang, He 5 ; Yan, Yunzhi 1 ;

作者机构： 1.Anhui Normal Univ, Sch Ecol & Environm, Wuhu 241002, Peoples R China

2.Anhui Normal Univ, Collaborat Innovat Ctr Recovery & Reconstruct Degr, Wuhu 241002, Peoples R China

3.Anhui Normal Univ, Minist Educ, Wuhu 241002, Peoples R China

4.Prov Key Lab Biot Environm & Ecol Safety Anhui, Wuhu 241002, Peoples R China

5.Anhui Acad Agr Sci, Fisheries Res Inst, Hefei, Peoples R China

6.Anhui Normal Univ, Sch Ecol & Environm, South Jiuhua Rd 189, Wuhu 241002, Anhui, Peoples R China

7.Anhui Normal Univ, Sch Ecol & Environm, South Jiuhua Rd 189, Wuhu, Anhui, Peoples R China

关键词： Copper; Intestine health; Transcriptome; Freshwater grouper

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 139 卷

页码：

收录情况： SCI

摘要： Copper (Cu) contamination is commonly found in both natural water environments and fish farms, and it can cause severe damage to different fish organs, but Cu-induced intestinal damage has been rarely studied. This study subjected three groups of freshwater grouper (Acrossocheilus fasciatus) (initial weight: 1.56 & PLUSMN; 0.10 g) to 0 mg/L, 0.01 mg/L, and 0.04 mg/L Cu2+ for 30 days, named Con, Cu0.01, and Cu0.04 groups, respectively. The histological observation indicated that the Cu0.04 group caused a significant decrease in villus length, lamina propria width, and muscular thickness compared to the Con group (P < 0.05). Additionally, the Cu0.04 group significantly increased intestinal superoxide dismutase (SOD), glutathione peroxidase (GPx), lysozyme (LZM) activities, as well as malondialdehyde (MDA) content than the Con group (P < 0.05). Meanwhile, the Cu0.01 and Cu0.04 groups showed significantly increased immunoglobulin M (IgM), complement 3 (C3), and glutathione (GSH) contents than the Con group (P < 0.05). Transcriptomic analysis revealed a total of 101 differentially expressed genes (DEGs), including 47 up-regulated and 54 down-regulated DEGs, were identified between the Cu0.04 and Con groups. Notably, the DEGs were mainly related to intestinal structure construction, immune functions, apoptosis, and resistance to DNA damage and pathogen infection. The findings suggest that chronic Cu exposure caused intestinal histological alterations, activated the antioxidative and immune systems, and induced systematic adaptation to cope with the physical barrier injury, DNA damage, and potential pathogen growth.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：安徽省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台