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Genome-wide scan for runs of homozygosity identifies candidate genes in Wannan Black pigs

文献类型： 外文期刊

作者： Wu, Xudong 1 ; Zhou, Ren 1 ; Zhang, Wei 1 ; Cao, Bangji 1 ; Xia, Jing 1 ; Wang, Caiyun 1 ; Zhang, Xiaodong 1 ; Chu, Mingx 1 ;

作者机构： 1.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Anhui, Peoples R China

2.Anhui Agr Univ, Anhui Prov Key Lab Local Livestock & Poultry Gene, Hefei 230036, Peoples R China

3.Anhui Acad Agr Sci, Key Lab Pig Mol Quantitat Genet, Anhui Prov Key Lab Livestock & Poultry Prod Safet, Inst Anim Husb & Vet Med, Hefei 230031, Anhui, Peoples R China

4.Chinese Acad Agr Sci, Inst Anim Sci, Key Lab Anim Poultry Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

关键词： Inbreeding Coefficient; Native Breed; Pig Breeding; Runs of Homozygosity

期刊名称：ANIMAL BIOSCIENCE

ISSN： 2765-0189

年卷期： 2021 年 34 卷 12 期

页码：

收录情况： SCI

摘要： Objective: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that can reveal inbreeding levels, selection pressure, and mating schemes. In this study, ROHs were evaluated in Wannan Black pigs to assess the inbreeding levels and the genome regions with high ROH frequency. Methods: In a previous study, we obtained 501.52 GB of raw data from resequencing (10x) of the genome and identified 21,316,754 single-nucleotide variants in 20 Wannan Black pig samples. We investigated the number, length, and frequency of ROH using resequencing data to characterize the homozygosity in Wannan Black pigs and identified genomic regions with high ROH frequencies. Results: In this work, 1,813 ROHs (837 ROHs in 100 to 500 kb, 449 ROHs in 500 to 1,000 kb, 527 ROHs in >1,000 kb) were identified in all samples, and the average genomic inbreeding coefficient (FROH) in Wannan Black pigs was 0.5234. Sixty-one regions on chromosomes 2, 3, 7, 8, 13, 15, and 16 harbored ROH islands. In total, 105 genes were identified in 42 ROH islands, among which some genes were related to production traits. Conclusion: This is the first study to identify ROH across the genome of Wannan Black pigs, the Chinese native breed of the Anhui province. Overall, Wannan Black pigs have high levels of inbreeding due to the influence of ancient and recent inbreeding due to the genome. These findings are a reliable resource for future studies and contribute to save and use the germplasm resources of Wannan Black pigs.

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