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Mutation of a Nucleotide-Binding Leucine-Rich Repeat Immune Receptor-Type Protein Disrupts Immunity to Bacterial Blight

文献类型： 外文期刊

作者： Tang, Jiuyou 1 ; Wang, Yiqin 1 ; Yin, Wenchao 1 ; Dong, Guojun 3 ; Sun, Kai 1 ; Teng, Zhenfeng 1 ; Wu, Xujiang 4 ; Wang, Shimei 5 ; Qian, Yangwen 6 ; Pan, Xuebiao 4 ; Qian, Qian 3 ; Chu, Chengcai 1 ;

作者机构： 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China

2.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100101, Peoples R China

3.Chinese Acad Agr Sci, China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou 310006, Peoples R China

4.Yangzhou Univ, Key Lab Plant Funct Genom Jiangsu Prov, Key Lab Crop Genet & Physiol Jiangsu Prov, Yangzhou 225009, Jiangsu, Peoples R China

5.Anhui Acad Agr Sci, Rice Res Inst, Hefei 230031, Peoples R China

6.Biogle Genome Editing Ctr, Changzhou 213125, Peoples R China

7.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100049, Peoples R China

期刊名称：PLANT PHYSIOLOGY （ 影响因子：8.34； 五年影响因子：8.972 ）

ISSN： 0032-0889

年卷期： 2019 年 181 卷 3 期

页码：

收录情况： SCI

摘要： Most characterized plant resistance proteins belong to the nucleotide-binding domain and Leu-rich repeat-containing (NLR) family. NLRs are present in an auto-inhibited state in the absence of specific pathogens, while gain-of-function mutations in NLRs usually cause autoimmunity. Here, we show that a gain-of-function mutation, weaker defense (wed), which caused a Phe-to-Leu substitution in the nucleotide-binding domain of a typical NLR in rice (Oryza sativa), led to enhanced susceptibility to Xanthomonas oryzae pv. Oryzae. The unexpected accumulation of salicylic acid (SA), along with downregulation of NONEXPRESSOR OF PR1 (NPR1), in wed indicates the potential presence of a feedback regulation loop of SA biosynthesis in rice. Epistasis analyses illustrated that SA accumulation and the NLR-associated components RAR1, OsRac1, and PhyB are dispensable for the wed phenotypes. Intriguingly, besides pattern-triggered immunity, effector-triggered immunity conferred by different resistance proteins, including Xa3/Xa26, Xa4, and Xa21, was also disturbed by wed to a certain extent, indicating the existence of shared regulatory mechanisms for various defense systems. The identification of wed therefore provides a unique system for genetic dissection of shared immune signaling pathways activated by different types of immune receptors.

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