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Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala

文献类型： 外文期刊

作者： Jiang, Yangyang 1 ; Liu, Zishang 2 ; Zhang, Ling 2 ; Liu, Wenbin 2 ; Li, Haiyang 1 ; Li, Xiangfei 2 ;

作者机构： 1.Anhui Acad Agr Sci, Fisheries Res Inst, Anhui Prov Key Lab Aquaculture & Stock Enhancement, Hefei 230031, Peoples R China

2.Nanjing Agr Univ, Coll Anim Sci & Technol, Key Lab Aquat Nutr & Feed Sci Jiangsu Prov, 1 Weigang Rd, Nanjing 210095, Peoples R China

关键词： stocking density; phosphatidylserine; stress response; antioxidant; fish culture

期刊名称：ANTIOXIDANTS （ 影响因子：6.0； 五年影响因子：6.7 ）

ISSN：

年卷期： 2024 年 13 卷 6 期

页码：

收录情况： SCI

摘要： This study was conducted to investigate the effects of dietary phosphatidylserine (PS) supplementation on the growth performance, stress response, non-specific immunity and antioxidant capacity of juvenile blunt snout bream (Megalobrama ambylcephala) cultured under a high stocking density. A 2 x 2 two-factorial design was adopted, including two stocking densities (10 and 20 fish/m3) and two dietary PS levels (0 and 50 mg/kg). After the 12-week feeding trial, the high stocking density significantly decreased the final weight; weight gain rate; specific growth rate; feed intake; nitrogen retention efficiency; plasma complement 3 (C3) level; albumin/globulin (ALB/GLB, A/G) ratio; activity of myeloperoxidase, lysozyme (LZM) and glutathione peroxidase (GPX); gpx transcription; and abundance of sirtuin3 (Sirt3) and nuclear factor erythroid-2-related factor 2 (Nrf2). However, it significantly increased the plasma levels of cortisol, glucose (GLU), lactic acid (LD), total protein and GLB; hepatic malondialdehyde (MDA) content; and sirt1 transcription. PS supplementation significantly increased the plasma ALB and C4 levels; the A/G ratio; the activity of LZM, CAT and GPX; the transcription of sirt1, nrf2, manganese-containing superoxide dismutase and catalase; and the Nrf2 abundance. However, it significantly decreased the plasma levels of cortisol, GLU and GLB, as well as the hepatic MDA content. In addition, there was a significant interaction between the stocking density and PS supplementation regarding the effects on the plasma LD, ALB, GLB and C3 levels; A/G ratio; hepatic CAT activity; and protein abundance of Sod2. In conclusion, PS supplementation can counteract the high stocking density-induced stress response, redox imbalance and immunosuppression in blunt snout bream.

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